CORE--MOUSE MUTAGENESIS FACILITY

核心——小鼠诱变设施

• 批准号: 6106290
• 负责人: DAVID WARSHAWSKY
• 金额: $ 13.47万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6106290
• 关键词: animal care; animal colony; biomedical facility; carcinogen testing; computer data analysis; laboratory mouse; mutagen testing; mutagens; veterinary medicine

The purpose of the mutagenesis core is to provide assistance to each of the research projects in the administration of mutagens and the subsequent follow-up and observation of the animals until they are assayed. The mutagens to be used in commin are ENU and 4-aminobiphenyl. DMBA will be used by Drs. Tishfield and Doetschman, and ionizing radiation by Drs. Stringer and Tishfield. The Cobalt-60 source, however, is not part of the mutagenesis core, but is available through Dr. Denman, a radiation biologist, in Radiology (see attached letter). The core also will provide adduct analysis, particularly for Dr. Doetschman's project.

诱变核心的目的是为每个 诱变者管理和随后的研究项目 随访和观察动物，直到被测定为止。 这 用于销物中的诱变剂是ENU和4-氨基苯基。 DMBA会 由Drs使用。 Tishfield和Doetschman，以及Drs的电离辐射。 Stringer和Tishfield。 但是，钴60来源不属于 诱变核心，但可通过辐射Denman博士获得 生物学家，放射学（请参阅附件）。 核心也将提供 加合物分析，特别是Doetschman博士的项目。