DROSOPHILA AS A NEW MODEL SYSTEM FOR DRUG ABUSE

果蝇作为药物滥用的新模型系统

• 批准号: 6175194
• 负责人: Colleen A McClung
• 金额: $ 1.82万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-05 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6175194
• 关键词: Drosophilidae; animal genetic material tag; behavioral /social science research tag; bioperiodicity; cocaine; disease /disorder model; drug abuse; drug habituation; ethology; gender difference; gene induction /repression; high performance liquid chromatography; immunocytochemistry; pharmacogenetics; polymerase chain reaction; psychopharmacology

DESCRIPTION: (Applicant's Abstract) The major focus of my laboratory is on functioning of the biogenic amine pathways in Drosophila, using cocaine and related drugs as selective agents. Major aims include: 1. Study of the genes and biological processes involved in responsiveness to cocaine and related drugs. 2. Characterization of the mechanisms by which the amine pathways are modulated as a function of i) sex, ii) time of subjective day, and iii) sensitization resulting from repeated exposure to cocaine. 3. Identification of brain specific regulatory elements of Ddc, and utilization of these elements to express novel gene products in aminergic cell subsets.

描述：（申请人的摘要） 我实验室的主要重点是生物胺的功能 果蝇中的途径，使用可卡因和相关药物作为选择性剂。 主要目的包括：1。研究基因和生物过程 参与对可卡因和相关药物的反应。 2。 调制胺途径的机制的表征 作为i）性的函数，ii）主观的时间，ii）敏化 反复接触可卡因而导致。 3。大脑的识别 DDC的特定调节元素以及这些元素的利用 在氨基能细胞亚群中表达新型基因产物。