JACKSON HEART STUDY--EXAM CENTER

杰克逊心脏研究中心--考试中心

• 批准号: 6316400
• 负责人: DANIEL W JONES
• 金额: $ 408.1万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6316400
• 关键词: African American; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; cardiovascular disorder prevention; clinical research; community; coronary disorder; disease /disorder etiology; geographic site; heart enlargement; heart failure; human middle age (35-64); human old age (65+); human subject; hypertension; kidney circulation disorder; longitudinal human study; minority health professional; minority institution research support; patient /disease registry; stroke

Despite encouraging declines over the past three decades, cardiovascular disease (CVD) remains the number one cause of death in the U.S. A number of risk factors for coronary heart disease (CHD) and stroke have been identified; however, relatively few population-based studies have examined CVD in a large group of African-Americans. Existing evidence indicated that death rates in Mississippi are the highest in the nation and particularly high among African-Americans. Between 1980 and 1995, the decline in CVD death rates has been the slowest among African-American men and women in Mississippi relative to other groups in the state and nation. The Jackson Heart Study (JHS) is a single-site prospective epidemiologic investigation of CVD among approximately 6,500 African-Americans ages 35 to 84, from Jackson, Mississippi metropolitan area. The primary objective of the JHS is to investigate the causes of CVD in African- Americans to learn how to best prevent this group of diseases in the future. More specific objectives include: (1) Identifying factors which influence the development and worsening of CVD in African-Americans, with an emphasis on Manifestations related to high blood pressure (such as enlargement of the left ventricle of the heart, coronary artery disease, heart failure, stroke and disorders affecting the blood vessels of the kidney). (2) Building research capabilities in minority institutions at the undergraduate and graduate level by developing partnerships between minority and majority institutions and enhancing participation of minority investigators in large-scale epidemiologic studies. (3) Attaching minority students to and preparing them for careers in public health and epidemiology. This project serves as the Coordinating Center where all data collected during the study will be managed, analysis of the data will be performed, and community involvement will be coordinated.

尽管在过去的三十年中令人鼓舞的是下降，但心血管疾病（CVD）仍然是美国死亡的第一大原因，已经确定了许多冠心病（CHD）和中风的危险因素；但是，相对较少的基于人群的研究检查了大量非裔美国人的CVD。现有证据表明，密西西比州的死亡率在美国最高，在非裔美国人中尤其高。在1980年至1995年之间，相对于该州和国家的其他群体，CVD死亡率的下降一直是密西西比州非裔美国人男女中最慢的。杰克逊心脏研究（JHS）是来自密西西比州大都会地区杰克逊（Jackson）的大约6,500名35至84岁的非裔美国人对CVD的单位前瞻性流行病学研究。 JHS的主要目的是调查非裔美国人CVD的原因，以学习如何在将来最好地预防这一疾病。更具体的目标包括：（1）识别影响非裔美国人CVD发育和恶化的因素，重点是与高血压有关的表现（例如，心脏左心室的增大，冠状动脉疾病，心力衰竭，心力衰竭，中风和影响肾脏血管的疾病）。 （2）通过建立少数族裔和多数机构之间的伙伴关系，并加强少数族裔研究人员参与大型流行病学研究，从而在本科和研究生层面建立研究能力。 （3）将少数族裔学生依靠并为公共卫生和流行病学的职业做准备。该项目是协调中心，在该中心将管理研究期间收集的所有数据，将对数据进行分析，并将协调社区参与。