Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American women

预防先兆子痫非裔美国女性产后心功能不全的指南指导管理和治疗 (GDMT)

• 批准号: 10675331
• 负责人: Sajid Shahul
• 金额: $ 34.36万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675331
• 关键词: Address; African American; Aspirin; Blood Pressure; Cardiac development; Cardiovascular Diseases; Cardiovascular Pregnancy Complications; Cessation of life; Clinical; Clinical Trials; Data; Deterioration; Development; EFRAC; Early Diagnosis; Evaluation; Functional disorder; Goals; Guidelines; Heart; Heart Rate; Heart failure; Hypertension; Incidence; Interdisciplinary Study; Intervention; Knowledge; Lead; Learning; Left; Life; Measures; Mediation; Medical; Methodology; Monitor; Morbidity - disease rate; Mothers; Myocardial dysfunction; Organ; Parents; Patients; Postpartum Hypertension; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnant Women; Prevention therapy; Pulmonary Edema; Race; Randomized; Randomized Controlled Trials; Recording of previous events; Stroke; Testing; Time; Ventricular Function; Visit; Woman; activin A; antenatal; blood pressure control; blood pressure elevation; blood pressure reduction; cardiogenesis; clinically relevant; cohort; compare effectiveness; epidemiology study; heart function; hypertensive; hypertensive heart disease; improved; innovation; mortality; pregnant; prevent; racial and ethnic; randomized trial

Project Summary/Abstract African American women are 60% more likely to have postpartum hypertension and are nearly three times more likely to die from preeclampsia than white women. Both during pregnancy and overall, hypertension in African American women is more severe and presents earlier in life. In addition, compared to other ethnic- racial groups, African American women have higher mortality rates from hypertension-related end-organ damage like heart failure and stroke. Currently, however, no proven interventions exist to prevent or mitigate the development of hypertensive heart disease during the postpartum period. Using a randomized mechanistic clinical trial of guideline-directed medical therapy for postpartum African American women with preeclampsia, we will advance knowledge of cardiac dysfunction in preeclampsia and its possible treatments. We pursue a specific aim to answer these questions. AIM 1 is a randomized trial to test whether guideline-directed medical therapy improves cardiac function and decreases blood pressure in postpartum African American women with preeclampsia. This project innovates methodologically to dramatically advance our understanding of a significant cause of morbidity and mortality in African American women.

项目摘要/摘要 非洲裔美国妇女患产后高血压的可能性高60％，几乎是三倍 比白人妇女更有可能死于先兆子痫。在怀孕期间和总体上，高血压 非洲裔美国妇女更加严重，生命更早。此外，与其他种族相比 种族群体，非洲裔美国妇女的死亡率较高 像心力衰竭和中风这样的伤害。但是，目前尚无可靠的干预措施来防止或减轻 产后高血压心脏病的发展。 使用针对产后非洲的指导指导药物治疗的随机机械临床试验 美国妇女具有先兆子痫的妇女，我们将提高对先兆子痫及其心脏功能障碍的了解 可能的治疗方法。我们追求一个特定的目标来回答这些问题。 AIM 1是一个随机试验进行测试 指导指导的医疗疗法是否改善心脏功能并降低血压 产后非洲裔美国妇女患有先兆子痫。该项目从方法上进行创新 极大地促进了我们对非裔美国人发病和死亡率的重要原因的理解 女性。