MACRONUTRIENTS & BLOOD PRESSURE--JACKSON INTERMAP CENTER

大量营养素

• 批准号: 2519527
• 负责人: DANIEL W JONES
• 金额: $ 0.56万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2519527
• 关键词: antihypertensive agents; blood pressure; cardiovascular disorder chemotherapy; diet; diet therapy; human subject; human therapy evaluation; hypertension; nutrient drug interaction; nutrition related tag; questionnaires; racial /ethnic difference; urinalysis

DESCRIPTION: (Adapted from Investigator's Abstract) INTERMAP is a basic epidemiologic investigation designed to help clarify unanswered questions on the role of dietary factors, particularly macronutrients, in the etiology of unfavorable blood pressure (BP) levels prevailing for a majority of middle- aged and older individuals in the United States. A particular focus is to help elucidate the role of these dietary factors in accounting for the even more adverse BP patterns of less educated population strata, e.g., in the U.S. in both less educated blacks and whites. INTERMAP's design is patterned after the tested INTERSALT model: large sample size of 5,200 persons (2,600 men and 2,600 women) ages 40-59 from 20 population samples of varied ethnicity, SES, and dietary habits in 4 countries (China, Japan, U.K. and the U.S.; 260 persons per sample). The investigators' group is to provide one (1) of the 8 diverse U.S. INTERMAP samples. Specific aims involve elucidating influences on BP of amount and type of protein, lipids, carbohydrates, and also amino acids, Ca, Mg, antioxidants, fiber, and caffeine. Primary hypotheses to be tested, with control for BMI, intake of alcohol, age, sex, and other confounders are as follow: dietary protein is inversely related to BP; inverse relations between education and BP are significantly accounted for by education-related differences in dietary protein intake; there is a direct relation to BP of dietary SFA, cholesterol, Keys score, starch; there is an inverse relation of PFA and P/S. Participants, randomly selected, are to provide one timed 24-hr. urine collection for assessment of Na, K, creatine, and urea, and they are to complete four 24-hr. dietary recalls. BP is to be measured twice at each of four clinic visits, with standardization and strict quality control of all procedures. The study is to be coordinated by two Coordinating Centers--Northwestern University, Chicago and London School of Hygiene & Tropical Medicine. Urinary determinations are to be made at a Central Laboratory in Leuven, Belgium. Twenty-four hour dietary recalls are to be converted into nutrients with use of the Nutrition Data System of the University of Minnesota's Nutrition Coordinating Center. Data analyses to test hypotheses are to be done at the London Coordinating Center. Overall study findings are to be used to estimate favorable impact on BP of multiple improvements in nutrition by populations. The investigators state that this should aid in making additional dietary recommendations toward the goal of primary prevention of hypertension and shifting BP distributions downward to avoid excess risk associated with present levels generally above optimal.

描述：（根据研究者的摘要进行了改编）Intermap是一个基本 流行病学调查旨在帮助澄清未解决的问题 关于饮食因素，尤其是大量营养素的作用 不利血压（BP）水平的病因 美国的大多数中年和老年人。 一个 特别的重点是帮助阐明这些饮食因素的作用 在解释教育程度较低的BP模式中 人口阶层，例如，在美国受过较低教育的黑人和 白人。 Intermap的设计是在经过测试的Intersalt之后图案的 型号：5,200人（2,600名男性和2,600名女性）的大样本大小 从20个种族，SES和 4个国家 /地区（中国，日本，英国和美国； 260）的饮食习惯 每个样本的人）。 调查人员小组将提供一（1）个 美国8种不同的媒介样品。 具体目的涉及阐明 影响蛋白质，脂质，碳水化合物的量和类型的BP的影响， 以及氨基酸，CA，MG，抗氧化剂，纤维和咖啡因。 主要假设要测试，并控制BMI，摄入 酒精，年龄，性别和其他混杂因素如下：饮食蛋白 与BP成反比； 教育与BP之间的逆关系 与教育相关的差异显着解释 饮食蛋白摄入；与饮食SFA的BP有直接关系， 胆固醇，钥匙得分，淀粉； PFA和 P/s。 随机选择的参与者将提供一个定时的24小时。 尿液收集用于评估Na，K，肌酸和尿素的尿液，它们 要完成四个24小时。饮食回忆。 BP应测量两次 在四个诊所就诊中的每一个，都有标准化和严格的质量 控制所有程序。 该研究将由两个协调 协调中心 - 北方大学，芝加哥和伦敦学校 卫生和热带医学。 要做出泌尿 在比利时鲁汶的一个中央实验室。 二十四小时饮食 召回将通过营养转化为营养 明尼苏达大学的营养协调数据系统 中心。 测试假设的数据分析将在伦敦进行 协调中心。 总体研究结果将用于估计 对BP的有利影响，从 人群。 调查人员指出，这应该有助于制作 针对初级预防目标的其他饮食建议 高血压和向下转移BP分布以避免过量 与当前水平相关的风险通常高于最佳。