EFFECT OF HYPOESTROGENISM ON BONE MINERAL DENSITY IN MARMOSETS

雌激素水平低下对狨猴骨矿物质密度的影响

• 批准号: 6116434
• 负责人: WENDY SALTZMAN
• 金额: $ 4.91万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116434
• 关键词: Mammalia; aging; behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; endocrine gland /system; growth /development; imaging /visualization /scanning; model design /development; psychology; reproductive system; skeletal system; women's health

OBJECTIVE To determine whether female marmosets undergo a reduction in bone mineral density following ovariectomy or socially induced hypoestrogenic anovulation. RESULTS Chronic reduction in estrogen causes a reduction in bone mineral density (BMD) and an increase in osteoporosis in most species in which it has been studied. In marmosets, socially subordinate females regularly become anovulatory and may remain hypoestrogenemic for extended periods of time. To determine whether marmosets might possess a mechanism to protect them from the deleterious skeletal consequences of hypoestrogenism, we examined the effect of ovariectomy-induced or socially induced hypoestrogenism on BMD. No differences in BMD were found between ovary-intact and ovariectomized females, or between dominant and subordinate females. A longitudinal study also failed to reveal any effects of ovariectomy on BMD. Thus, marmosets may possess a unique adaptation protecting them from hypoestrogenism-induced bone loss, and might provide a novel model for the investigation and treatment of osteoporosis. FUTURE DIRECTIONS We plan to confirm and extend our preliminary findings and to begin to investigate the possible biochemical and cellular mechanisms by which estrogen depletion is decoupled from bone loss in female marmosets. KEY WORDS dual-energy X-ray absorptiometry, skeletal system, osteoporosis FUNDING Saltzman, W., C, FED, AG15621, $62,000, NIH. PUBLICATIONS Colman, R.J., W. Saltzman, D.H. Abbott, J.W. Kemnitz, and N. Binkley. 1998. Lack of estrogen depletion bone loss in common marmosets. International Symposium on Biology of Menopause, Newport Beach, CA. [A]

目的 确定雌性狨猴是否经历过 卵巢切除或社交后骨矿物质密度降低 诱发低雌激素性无排卵。 结果 慢性减少 雌激素会导致骨矿物质密度（BMD）降低， 在大多数已研究的物种中，骨质疏松症有所增加。 在狨猴中，处于社会从属地位的雌性经常变得 无排卵，可能会长时间保持低雌激素水平 时间。 确定狨猴是否拥有一种机制 保护他们免受有害的骨骼后果 雌激素低下症，我们检查了卵巢切除术引起的或 社会引起的 BMD 雌激素低下症。 BMD 没有差异 发现于卵巢完整和卵巢切除的雌性之间，或之间 女性占主导地位和从属地位。 一项纵向研究也未能 揭示卵巢切除术对 BMD 的影响。 因此，狨猴可能拥有 独特的适应性保护它们免受雌激素低下引起的骨质破坏 损失，并可能为调查和分析提供一个新的模型 治疗骨质疏松症。 未来方向 我们计划确认并 扩展我们的初步发现并开始调查 雌激素可能通过的生化和细胞机制 雌性狨猴的骨质消耗与骨质流失无关。 关键词 双能X射线骨密度仪, 骨骼系统, 骨质疏松 资金 Saltzman, W., C, FED, AG15621, 62,000 美元，NIH。 出版物 Colman, R.J.、W. Saltzman、D.H. Abbott、J.W.凯姆尼茨和 N.宾克利。 1998.普通狨猴缺乏雌激素消耗导致骨质流失。 国际更年期生物学研讨会，加利福尼亚州纽波特海滩。 [一个]