CORE--NEUROIMAGING

核心--神经影像

• 批准号: 6315199
• 负责人: KEITH R. THULBORN
• 金额: $ 15.83万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6315199
• 关键词: Alzheimer's disease; bioimaging /biomedical imaging; biomedical facility; brain imaging /visualization /scanning; human subject; image processing; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; positron emission tomography

The Neuroimaging Core will continue to provide support for all neuroimaging studies performed on AD and related dementias by ADRC and ADRC-associated investigators. The Core builds on its successes with the development and distribution of methodologies for acquisition and interpretation of a comprehensive functional magnetic resonance imaging (MRI) protocol at 3.0 Tesla and to extend services to encompass positron emission tomography (PET). Procedures for acquiring, archiving and managing all the clinical MR imaging examinations performed on patients referred for ADRC evaluation are in place. Ready access to fMRI technology for paradigm design and image analysis continues to encourage new investigators and novel approaches into AD research. Based on current results from the Core, such fMRI studies offer new insight into innate brain responses to disease and subsequent dysfunction. Such functional parameters may prove useful clinically. As PET remains a focus of activity within the ADRC and uses MRI resources, support for this modality has also been encompassed into the Core. This expanded role should serve to foster efficient use of combined imaging modalities and facilitate communication between investigators using these resources. Through interactions with other research grants, the expanded Core faculty enable greater access to a broader scope of support and expertise without substantial increase in cost.

神经成像核心将继续为ADRC和ADRC相关研究者对AD和相关痴呆症进行的所有神经影像学研究提供支持。核心是基于其成功的基础，该方法的开发和分布是在3.0 Tesla处获得全面功能磁共振成像（MRI）协议的方法，并扩展了服务以包含正电子发射断层扫描（PET）。获取，归档和管理对参考ADRC评估的患者进行的所有临床MR成像检查的程序均已到位。可以访问用于范式设计和图像分析的FMRI技术，继续鼓励新的研究人员和新的AD研究方法。基于目前的核心结果，此类功能磁共振成像研究提供了对疾病对疾病和随后功能障碍的先天大脑反应的新见解。此类功能参数可能在临床上有用。由于PET仍然是ADRC内部活动的重点并使用MRI资源，因此对这种方式的支持也已包含在核心中。这种扩展的角色应有助于促进联合成像方式的有效利用，并促进使用这些资源之间的研究人员之间的沟通。通过与其他研究补助金的互动，扩大的核心教师可以在不大幅增加成本的情况下更广泛地获得更广泛的支持和专业知识。