CORE--IMAGING AND GENETICS

核心——影像学和遗传学

• 批准号: 6578756
• 负责人: GARY William SMALL
• 金额: $ 22.86万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578756
• 关键词: Alzheimer's disease; bioimaging /biomedical imaging; biomedical facility; clinical research; dementia; digital imaging; family genetics; genetic susceptibility; genotype; health care facility information system; human genetic material tag; human old age (65+); human subject; longitudinal human study; magnetic resonance imaging; neurogenetics; neuropathology; positron emission tomography

The Imaging and Genetics Core builds upon existing strengths at UCLA in resources and talent in these two technologies, as well as initial successes in combining imaging and genetics in the study of milder forms of age-related memory loss. The Imaging and Genetics ore (Dr. Small, Leader) will include an Imaging Subcore (Dr. Mega, Leader) and a Genetics Subcore (Dr. Geschwind, Leader), which will bring together investigators and data from both scientific domains to provide a resource that will accomplish seen specific aims that include: (1) collecting longitudinal structural (MRI) and functional (FDG-PET) imaging data on an estimated 30 mild AD patients, 30 persons with minimal cognitive impairment, and 30 cognitively intact elderly controls every year; (2) providing digital access to the longitudinal imaging database for ADRC investigators with links to the clinical and genetic database; (3) providing the means for investigators to digitally analyze archived brain scans; (4) drawing blood to prepare genomic DNA for all ADRC patients with AD and fronto-temporal dementia (FTD); (5) Performing APOE genotyping on sporadic and familial AD and FTD patients, as well as controls; (6) completing a risk factor questionnaire for patients and controls to enhance the power of genetic and environmental risk factor analysis; and (7) facilitating recruitment of families with AD and FTD for ongoing linage studies in collaboration with investigators at other ADCs. The Core will support at least 13 identified protocols, in response to the last committee review. ADRC investigators will be able to access the database and identify appropriate subjects for further follow-up imaging analysis a specific dataset including 3T MRI and FDG- PET data. The Genetics Subcore will establish a genetics resource for the study of dementia at UCLA. This Subcore will provide another dimension of interface with neuropathological, imaging and clinical data, and support clinical and basic research efforts. Since sample collection is a major bottleneck for many genetic studies, the availability of DNA from a large number of sporadic and familial AD and FTD patients and controls will vastly improve the ability to rapidly replicate genetic findings and to test novel genetic hypotheses.

成像和遗传学核心基于UCLA的现有优势 这两种技术的资源和人才以及初始 在较温和形式的研究中结合成像和遗传学的成功 与年龄有关的记忆损失。成像和遗传学矿石（Small博士， 领导者）将包括一个成像子核（Mega博士，领导者）和 遗传学子核心（Geschwind博士，领导者），它将聚集在一起 研究人员和来自两个科学领域的数据提供 将完成所见特定目的的资源，其中包括：（1） 收集纵向结构（MRI）和功能（FDG-PET） 估计有30名温和广告患者的成像数据，30人 最小的认知障碍和30个认知完整的老年对照 每年; （2）提供数字访问纵向成像 与临床和遗传有关的ADRC研究人员的数据库 数据库; （3）为研究人员提供数字分析的手段 存档的脑部扫描； （4）抽血为所有人准备基因组DNA ADRC AD和额叶痴呆症患者（FTD）； （5）表演 对零星和家族性AD和FTD患者的APOE基因分型以及 控件； （6）为患者完成危险因素问卷调查，并 控制以增强遗传和环境风险因素的力量 分析; （7）促进AD和FTD家庭的招聘 与其他研究人员合作进行持续的线路研究 ADC。核心将至少支持13个确定的协议， 回应上次委员会审查。 ADRC调查人员将能够 访问数据库并确定适当的主题以进一步 后续成像分析一个特定数据集，包括3T MRI和FDG- 宠物数据。遗传学子核将建立遗传学资源 UCLA痴呆症的研究。该子核心将提供另一个 与神经病理学，成像和临床的界面维度 数据，并支持临床和基础研究工作。自样品以来 收集是许多遗传研究的主要瓶颈， 来自大量零星和家族广告的DNA可用性以及 FTD患者和对照将大大提高快速的能力 复制遗传发现并检验新的遗传假设。