CORE--IMAGING AND GENETICS

核心——影像学和遗传学

• 批准号: 6578756
• 负责人: GARY William SMALL
• 金额: $ 22.86万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578756
• 关键词: Alzheimer's disease; bioimaging /biomedical imaging; biomedical facility; clinical research; dementia; digital imaging; family genetics; genetic susceptibility; genotype; health care facility information system; human genetic material tag; human old age (65+); human subject; longitudinal human study; magnetic resonance imaging; neurogenetics; neuropathology; positron emission tomography

The Imaging and Genetics Core builds upon existing strengths at UCLA in resources and talent in these two technologies, as well as initial successes in combining imaging and genetics in the study of milder forms of age-related memory loss. The Imaging and Genetics ore (Dr. Small, Leader) will include an Imaging Subcore (Dr. Mega, Leader) and a Genetics Subcore (Dr. Geschwind, Leader), which will bring together investigators and data from both scientific domains to provide a resource that will accomplish seen specific aims that include: (1) collecting longitudinal structural (MRI) and functional (FDG-PET) imaging data on an estimated 30 mild AD patients, 30 persons with minimal cognitive impairment, and 30 cognitively intact elderly controls every year; (2) providing digital access to the longitudinal imaging database for ADRC investigators with links to the clinical and genetic database; (3) providing the means for investigators to digitally analyze archived brain scans; (4) drawing blood to prepare genomic DNA for all ADRC patients with AD and fronto-temporal dementia (FTD); (5) Performing APOE genotyping on sporadic and familial AD and FTD patients, as well as controls; (6) completing a risk factor questionnaire for patients and controls to enhance the power of genetic and environmental risk factor analysis; and (7) facilitating recruitment of families with AD and FTD for ongoing linage studies in collaboration with investigators at other ADCs. The Core will support at least 13 identified protocols, in response to the last committee review. ADRC investigators will be able to access the database and identify appropriate subjects for further follow-up imaging analysis a specific dataset including 3T MRI and FDG- PET data. The Genetics Subcore will establish a genetics resource for the study of dementia at UCLA. This Subcore will provide another dimension of interface with neuropathological, imaging and clinical data, and support clinical and basic research efforts. Since sample collection is a major bottleneck for many genetic studies, the availability of DNA from a large number of sporadic and familial AD and FTD patients and controls will vastly improve the ability to rapidly replicate genetic findings and to test novel genetic hypotheses.

成像和遗传学核心建立在加州大学洛杉矶分校的现有优势之上 这两项技术的资源和人才，以及初始 将影像学和遗传学结合起来研究较温和的疾病取得了成功 与年龄相关的记忆丧失。成像和遗传学矿石（Small 博士， Leader）将包括一个成像子核心（Dr. Mega，Leader）和一个 遗传学子核心（Geschwind 博士，领导者），它将汇集 研究人员和来自两个科学领域的数据提供了 将实现特定目标的资源，包括：(1) 收集纵向结构 (MRI) 和功能 (FDG-PET) 估计 30 名轻度 AD 患者、30 名患有 AD 患者的影像数据 轻度认知障碍，以及 30 名认知完好的老年对照 每年; (2) 提供纵向成像的数字访问 为 ADRC 研究人员提供的数据库，其中包含与临床和遗传相关的链接 数据库; (3) 为研究者提供数字化分析的手段 存档的脑部扫描； (4) 抽血为所有人准备基因组DNA ADRC 患有 AD 和额颞叶痴呆 (FTD) 的患者； (5) 表演 对散发性和家族性 AD 和 FTD 患者以及 FTD 患者进行 APOE 基因分型 控制； (6) 填写患者危险因素调查问卷 加强遗传和环境风险因素力量的控制 分析; (7) 促进 AD 和 FTD 家庭的招募 与其他研究人员合作进行正在进行的谱系研究 ADC。该核心将支持至少 13 个已确定的协议， 对上次委员会审查的答复。 ADRC 调查人员将能够 访问数据库并确定进一步的适当主题 后续成像分析特定数据集，包括 3T MRI 和 FDG- 正电子发射断层扫描数据。遗传学子核心将建立遗传资源 加州大学洛杉矶分校的痴呆症研究。该子核心将提供另一个 与神经病理学、影像学和临床的接口维度 数据，并支持临床和基础研究工作。自样品 收集是许多遗传学研究的主要瓶颈 从大量散发性和家族性 AD 中获取 DNA 以及 FTD 患者和对照将大大提高快速诊断的能力 复制遗传发现并测试新的遗传假设。