PHYSIOLOGICAL AND METABOLIC IMAGING

生理和代谢成像

• 批准号: 6356590
• 负责人: KEITH R. THULBORN
• 金额: $ 16.75万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6356590
• 关键词: bioimaging /biomedical imaging; body water; brain circulation; brain imaging /visualization /scanning; eye movements; human subject; lactates; magnetic resonance imaging; method development; perfusion; phosphorylation; positron emission tomography; visual stimulus

This Project follows the central theme of this Center proposal in refining existing and developing new fMRI techniques capable of investigating cognitive function. It utilizes the entire range of resources and expertise of the Center by customizing each aspect of the fMRI experiment including instrumentation, acquisition software and signal processing. Other Projects use Bold contrast fMRI to probe cognitive processing in normal subjects with the underlying reasonable assumption that changes in Bold contrast reflect changes in neuronal activity in a monotonically increasing manner. The nature of the Bold contrast response is complex. This Project develops methods of arterial water labeling (AWL) and tissue lactate imaging (TlacC) to provide alternative and possibly quantitative probes of neuronal activity. AWL is a potentially quantitative non-invasive measure of resting regional brain perfusion that is to be calibrated against regional CBF as measured by PET. If quantitative AWL can be developed to measure resting state and changes in perfusion, a potential confounding source of differences in Bold responses among normal individuals can be measured and therefore controlled. Lactate imaging is a significant challenge in all aspects of non-water MRI but is now within reach and provides a probe metabolically close to neuronal activity. This approach has required single stimulus synchronization strategies to be developed. TlacC, based on transient changes in tissue lactate content due to neuronal activity, avoids the complexities of interpreting the downstream and slower hemodynamic responses of Bold. This Project interacts with a Core in applying stimulus-synchronized image acquisition to investigate single stimulus responses at high temporal resolution using the Bold and TlacC methods. Simple paradigms are to be used before moving to the other Projects with more complex paradigms. Focused effort on technological advancement of alternatives to Bold contrast and enhancement of the temporal response of fMRI are ideally suited to the uniquely equipped MR Research Center.

该项目遵循该中心提议的中心主题 完善现有和开发的新功能磁共振成像技术 研究认知功能。 它利用了整个范围 通过自定义中心的资源和专业知识 功能磁共振成像实验，包括仪器，获取软件 和信号处理。 其他项目使用大胆的对比FMRI来探测认知处理 在正常受试者中，具有基本合理假设 大胆对比的变化反映了A中神经元活性的变化 单调增加的方式。大胆对比的本质 响应很复杂。该项目开发了动脉水的方法 标记（awl）和组织乳酸成像（TLACC）提供 神经元活性的替代性和可能的​​定量探针。 AWL是一种潜在的定量非侵入性衡量 针对区域CBF进行校准的区域大脑灌注 如宠物测量。 如果可以开发定量锥 测量静止状态和灌注变化，潜力 正常之间的大胆响应差异的混淆来源 可以测量个人并因此受到控制。 在非水的各个方面，乳酸成像是一个重大挑战 MRI，但现在可以触及，并提供了一个代谢上的探测器 神经元活性。 这种方法需要单个刺激 要制定的同步策略。 TLACC，基于瞬态 由于神经元活性引起的组织乳酸含量的变化，避免了 解释下游和较慢的血液动力学的复杂性 大胆的回应。 该项目与核心在应用刺激同步时相互作用 图像获取以研究高的单个刺激反应 使用BOLD和TLACC方法的时间分辨率。 简单的 在转到其他项目之前，应使用范式 更复杂的范例。专注于技术进步 大胆对比度和时间增强的替代方案 fMRI的响应非常适合具有独特配备的MR 研究中心。