MAINTAINING HIV RISK REDUCTION AMONG NEEDLE EXCHANGERS

保持换针者感染艾滋病毒的风险

• 批准号: 6287491
• 负责人: Michael D Stein
• 金额: $ 44.3万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6287491
• 关键词: AIDS education /prevention; antidepressants; behavioral /social science research tag; clinical depression; clinical research; communicable disease control; disease /disorder proneness /risk; health behavior; high risk behavior /lifestyle; human subject; hypodermic needle; intravenous drug abuse; mental disorder chemotherapy

DESCRIPTION (Applicant's abstract): Over the past decade, intravenous drug users (IDUs) have surprised policy makers and researchers by exhibiting large-scale HIV risk reduction, despite the fact that the majority of drug injectors axe unwilling or unable to enter formal drug treatment. Needle exchange programs offer direct contact with drug users who have initiated HIV risk reduction. The maintenance of risk reduction among out-of-treatment IDUs has never been studied. In the present study we suggest that the presence of depression among needle exchangers who have gone at least six months without sharing injection equipment places them at risk for a return to unsafe drug injection behaviors. Using a randomized, controlled design, enrolling 265 needle exchange clients in Providence, Rhode Island, this study provides the opportunity to treat the patient's depressive symptoms and thereby further sustain HIV risk reduction. The Primary Aim of the present application is: To test if treatment for depression using antidepressant medication will maintain safe injection behaviors among needle exchange clients compared to a treatment-as-usual condition. The Secondary Aim is: To determine if antidepressant medication treatment will reduce depressive symptom scores compared to the treatment-as-usual condition. The Tertiary Aims are: 1) To determine if reduction in depressive symptoms is associated with maintenance of safe injection behaviors, and 2) To describe specific patient characteristics associated with maintenance of safe injection behaviors. Given that many injection drug users (IDUs) continue to inject drugs over decades, maintaining HIV risk reduction is a critical public health problem. Our results will have policy implications for needle exchange programs where many IDUs have initiated HIV risk reduction.

描述（申请人摘要）：过去十年，静脉注射药物 用户 (IDU) 的表现令政策制定者和研究人员感到惊讶 大规模降低艾滋病毒风险，尽管事实上大多数药物 注射者不愿意或无法接受正式的戒毒治疗。针 交流项目提供与感染艾滋病毒的吸毒者的直接接触 降低风险。保持治疗外吸毒者风险降低 从未被研究过。在本研究中，我们建议存在 至少六个月没有更换针头的人出现抑郁症 共用注射设备使他们面临再次使用不安全药物的风险 注射行为。采用随机对照设计，招募了 265 名 罗德岛州普罗维登斯的针头交换客户，这项研究提供了 治疗患者抑郁症状的机会，从而进一步 持续降低艾滋病毒风险。本申请的主要目的是： 测试使用抗抑郁药物治疗抑郁症是否会持续 与针头交换客户相比，安全注射行为 治疗如常。次要目标是：确定是否 抗抑郁药物治疗会降低抑郁症状评分 与正常治疗情况相比。第三目标是： 1) 确定抑郁症状的减少是否与维持 安全注射行为，以及 2) 描述特定的患者特征 与维护安全注射行为有关。鉴于许多 注射吸毒者 (IDU) 几十年来继续注射毒品，维持 降低艾滋病毒风险是一个重要的公共卫生问题。我们的结果将会有 对许多注射吸毒者发起的针头交换计划的政策影响 降低艾滋病毒风险。