PROTEIN/LIPID INTERACTION

蛋白质/脂质相互作用

• 批准号: 6125710
• 负责人: ROBERT B GENNIS
• 金额: $ 16.78万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-01-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6125710
• 关键词: Escherichia coli; Raman spectrometry; Rhodospirillales; active sites; bacterial proteins; chemical binding; copper; crystallization; cytochrome oxidase; electron spin resonance spectroscopy; electron transport; enzyme mechanism; enzyme structure; heme; hydrogen transport; infrared spectrometry; interferometry; intermolecular interaction; laboratory mouse; ligands; membrane lipids; membrane proteins; microorganism metabolism; oxidation reduction reaction; protein degradation; protein sequence; respiratory enzyme; site directed mutagenesis; ubiquinone

项目成果

A pathogenic mutation in cytochrome c oxidase results in impaired proton pumping while retaining O(2)-reduction activity.

细胞色素 c 氧化酶的致病性突变会导致质子泵受损，同时保留 O(2) 还原活性。

• DOI: 10.1016/j.bbabio.2010.01.027
• 发表时间: 2010
• 期刊: Biochimica et biophysica acta
• 作者: Namslauer,Ida;Lee,HyunJu;Gennis,RobertB;Brzezinski,Peter
• 通讯作者: Brzezinski,Peter

Heme-heme and heme-ligand interactions in the di-heme oxygen-reducing site of cytochrome bd from Escherichia coli revealed by nanosecond absorption spectroscopy.

通过纳秒吸收光谱揭示大肠杆菌细胞色素 bd 的二血红素氧还原位点中的血红素-血红素和血红素-配体相互作用。

• DOI: 10.1016/j.bbabio.2010.05.010
• 发表时间: 2010
• 期刊: Biochimica et biophysica acta
• 作者: Rappaport,Fabrice;Zhang,Jie;Vos,MartenH;Gennis,RobertB;Borisov,VitaliyB
• 通讯作者: Borisov,VitaliyB

Single-electron photoreduction of the P(M) intermediate of cytochrome c oxidase.

细胞色素 c 氧化酶 P(M) 中间体的单电子光还原。

• DOI: 10.1016/j.bbabio.2006.07.003
• 发表时间: 2006
• 期刊: Biochimica et biophysica acta
• 作者: Siletsky,SergeyA;Han,Dan;Brand,Sue;Morgan,JoelE;Fabian,Marian;Geren,Lois;Millett,Francis;Durham,Bill;Konstantinov,AlexanderA;Gennis,RobertB
• 通讯作者: Gennis,RobertB

Functional importance of Glutamate-445 and Glutamate-99 in proton-coupled electron transfer during oxygen reduction by cytochrome bd from Escherichia coli.

Glutamate-445 和 Glutamate-99 在大肠杆菌细胞色素 bd 氧还原过程中质子耦合电子转移中的功能重要性。

• DOI: 10.1016/j.bbabio.2018.04.012
• 发表时间: 2018
• 期刊: Biochimica et biophysica acta. Bioenergetics
• 作者: Murali,Ranjani;Gennis,RobertB
• 通讯作者: Gennis,RobertB

Electron and proton transfer in the ba(3) oxidase from Thermus thermophilus.

嗜热栖热菌的 ba(3) 氧化酶中的电子和质子转移。

• DOI: 10.1007/s10863-008-9157-7
• 发表时间: 2008
• 期刊: Journal of bioenergetics and biomembranes
• 影响因子: 3
• 作者: Smirnova,IrinaA;Zaslavsky,Dmitry;Fee,JamesA;Gennis,RobertB;Brzezinski,Peter
• 通讯作者: Brzezinski,Peter