OCCUPATIONAL EXPOSURES AND RISK OF BREAST CANCER

职业暴露和乳腺癌风险

• 批准号: 6173553
• 负责人: John Edward Vena
• 金额: $ 12.42万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2002-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6173553
• 关键词: breast neoplasms; cancer risk; carbopolycyclic compound; clinical research; electromagnetic radiation; female; histology; human subject; interview; occupational health /safety; solvents; statistics /biometry; toxicology; women's health

Recent estimates indicate that only about 40 percent of breast cancer cases can be explained by accepted and suspected risk factors. Exposures to chemical and physical agents in the workplace of women have not been studied adequately. Thus, the object of the present protocol is to determine whether occupational exposures to selected chemical and physical agents is associated with increased risks of pre- and postmenopausal breast cancer. A population-based, case-control study of pre-and postmenopausal breast cancer incidence among women aged 40 to 79 years was conducted in western New York State between 1986 and 1991. Only new, histologically-confirmed primary cases of malignant breast cancer from all major hospitals in the region were enrolled (301 premenopausal and 439 postmenopausal). A population-based control group was recruited and was frequency-matched to case subjects on age and county of residence. Face-to-face interviews by trained nurse- interviewers were carried out and information on a wide array of accepted and potential risk factors was obtained. Standardized lifetime occupational histories were also obtained and these included details regarding place of employment, duties and activities associated with each job. For all 1,550 subjects, the job histories will be sent to a team of expert industrial hygienists and chemists at the Institut Armand-Frappier who will then attribute exposure to about 300 agents using a method developed by Siemiatycki and colleagues. The team has considerable experience in coding these types of job histories and will collaborate with hygienists in Buffalo. The occupational information present in the job descriptions is sufficiently detailed to capture the idiosyncracies of each person's job; thus, this system will minimize exposure misclassification. Statistical analyses, including logistic regression and generalized additive modeling techniques, will be carried out to assess the role of occupational exposures with a focus on polycyclic aromatic hydrocarbons, specific organic solvents and electromagnetic fields. Analyses will be conducted separately for the pre- and postmenopausal groups and will be combined where appropriate. Identification of agents whose exposures are amenable to modification may allow for new public health initiatives to reduce risk. This timely investigation should make an important contribution to our limited understanding of occupational risk factors for breast cancer.

最近的估计表明，只有约40％的乳腺癌 案件可以通过接受和怀疑的危险因素来解释。 妇女工作场所中化学和物理药物的暴露有 没有得到充分的研究。 因此，本协议的对象 是确定职业暴露于选定的化学物质和 物理药物与前和前的风险增加有关 绝经后乳腺癌。 基于人群的病例对照研究 40岁的妇女的绝经前后乳腺癌发生率 1986年至79年在纽约州西部进行 1991。只有新的，组织学确认的主要病例 该地区所有主要医院的乳腺癌均已招募（301 绝经前和439个绝经后）。 基于人群的对照组 被招募，并在年龄和 居住县。 受过训练的护士面对面面试 - 进行了访调员，并提供了一系列的信息 获得了被公认和潜在的危险因素。 标准化的寿命 还获得了职业历史，其中包括 关于就业地点，关税和活动 每个工作。对于所有1,550个受试者，工作历史将被发送到 研究所的专家工业卫生学家和化学家团队 然后，Armand-Frappier将归因于大约300个代理商 使用Siemiatycki及其同事开发的方法。团队有 在编码这些类型的工作历史方面有丰富的经验 与布法罗的卫生学家合作。 职业信息 在作业描述中存在足够详细的信息以捕获 每个人的工作的特质；因此，该系统将最小化 暴露分类错误。 统计分析，包括逻辑 回归和广义添加剂建模技术将被携带 评估职业暴露的作用，重点 多环芳烃，特定的有机溶剂和 电磁场。 分析将分别进行 绝经前和绝经后组，将在适当的情况下合并。 识别其暴露于修改的代理 可能允许新的公共卫生计划降低风险。 这个及时 调查应为我们的有限公司做出重要贡献 了解乳腺癌的职业危险因素。