BREAST CANCER RISK--RESIDENTIAL ENVIRONMENT AND GENETICS

乳腺癌风险——居住环境和遗传学

• 批准号: 6166370
• 负责人: JO L. FREUDENHEIM
• 金额: $ 11.55万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6166370
• 关键词: age at pregnancy; benzene; breast neoplasms; cancer risk; carbopolycyclic compound; clinical research; cytochrome P450; environment related neoplasm /cancer; environmental exposure; female; gene environment interaction; genetic susceptibility; geographic site; glutathione transferase; housing; human middle age (35-64); human old age (65+); human subject; industry; information systems; menopause; menstrual cycle; neoplasm /cancer epidemiology; neoplasm /cancer genetics; women's health

DESCRIPTION: (Applicant's Description) Breast Cancer Risk: Residential Environment and Genetics There is evidence that environmental factors related to industrialization may be important in breast cancer etiology. There has been little study of proximity to potentially toxic industrial sites as breast cancer risk factors. We propose to conduct a case-control study to examine location of residence during adult life in relation to breast cancer risk. The aims of the study are: 1) To investigate distance from steel mills, chemical factories, and other industrial sites of the residence as risk factors. The time periods to be examined will be (1 ) the primary residence during the period between menarche and first pregnancy (if any, otherwise menopause) and (2) residence (s) 10 and 20 years ago; 2) To examine estimated exposure to benzene and to PAHs based on residential exposure during these time periods as risk factors. Secondary objectives are: 3) To examine genetic variability in metabolism by NQ01, GST M1-1 , GST P1-1 and CYP 1A1 in relation to these exposures and breast cancer risk; 4) To evaluate all adult residences in relation to distance from potentially important exposures (steel mills, chemical factories, etc.) and risk; 5) To examine estimated exposure to benzene and to PAHs during the entire adult life and risk. We will use data from an ongoing case-control study of breast cancer in Erie and Niagara Counties including approximately 1000 cases of incident, primary, histologically-confirmed breast cancer and more than 2000 controls, age 35-79, frequency-matched to cases. About 75 percents of participants in the original study lived in these counties at the time of their menarche. Addresses for the women at the time of their birth and at menarche will be geocoded using a Geographic Information System (GIS). Historical data will be collected regarding location of potentially important industrial sites. We will calculate odds ratios and 95 percents confidence intervals for distance from each category of potential exposure and for an index of probable level of exposure to PAHs and to benzene and we will examine risk within categories stratified on genotype. This is a unique and cost effective opportunity to examine a hypothesis of potentially great public health importance in a relatively residentially stable population.

描述：（申请人的描述） 乳腺癌风险：住宅环境和遗传学 有证据表明，与工业化有关的环境因素可能 在乳腺癌病因中很重要。几乎没有研究 靠近潜在有毒工业场所是乳腺癌危险因素。 我们建议进行一项病例对照研究以检查居住地点 在成人生活中，与乳腺癌风险有关。研究的目的 是：1）调查与钢厂，化学工厂和 该住所的其他工业场所是风险因素。时间段 被检查将是（1）在此期间的主要住所 初潮和第一次怀孕（如果有的话，否则更年期）和（2）居住 （S）10年前； 2）检查估计接触苯和 在这些时期内基于住宅暴露的PAH作为风险因素。 次要目标是：3）检查由 NQ01，GST M1-1，GST P1-1和CYP 1A1与这些暴露有关 乳腺癌风险； 4）评估所有成人住宅 距潜在重要暴露的距离（钢厂，化学 工厂等）和风险； 5）检查估计接触苯和 PAH在整个成人生活和风险中。我们将使用正在进行的数据 伊利和尼亚加拉县乳腺癌的病例对照研究包括 大约1000例事件，原发性，组织学确认的乳房 癌症和2000多个对照，年龄在35-79岁之间，频率与病例匹配。 原始研究中约有75名参与者居住在这些研究中 初级成年时期的县。妇女的地址 他们的诞生和初潮将使用地理信息进行地理编码 系统（GIS）。将收集有关位置的历史数据 潜在的重要工业站点。 我们将计算赔率和95 距离潜在类别距离的percents置信区间 暴露和可能会暴露于PAH和苯的索引 我们将检查基因型分层的类别中的风险。这是一个 独特且成本效益的机会，以检查潜在的假设 在相对稳定的相对稳定中，公共健康的重要性非常重要 人口。