AGE AND CONTROL OF HUMAN SKIN BLOOD FLOW

年龄和人类皮肤血流的控制

• 批准号: 6090789
• 负责人: W. LARRY KENNEY
• 金额: $ 41.25万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6090789
• 关键词: age difference; baroreceptors; bioimaging /biomedical imaging; body temperature regulation; clinical research; combination chemotherapy; environmental stressor; estrogens; exercise; gender difference; hormone therapy; human old age (65+); human subject; hyperthermia; nitric oxide; postmenopause; progestins; psychometrics; skin circulation; ultrasound blood flow measurement; vasoconstriction; vasodilation; young adult human (21-34)

DESCRIPTION (Adapted from the Applicant's Abstract): In men and women over the age of 65, the non-acral skin blood flow (SkBF) response to hyperthermia is significantly attenuated. The site of this age-related defect involves the active vasodilator system, a non-adrenergic efferent pathway unique to human skin. The proposed series of studies will systematically examine potential mechanisms through which the negative effects of aging and the positive effects of estrogen therapy are exerted. In older and younger men and women and in post-menopausal women taking various types of hormone replacement therapy or no therapy, the PI plans to (a) examine spatial distribution and heterogeneity of active cutaneous vasodilation to determine whether changes in functional capillary plexus unit density and/or flow contribute to alterations in SkBF using scanning laser-Doppler imaging; (b) examine the magnitude, spatial distribution, and heterogeneity of reflex-mediated noradrenergic cutaneous vasoconstriction during whole-body cooling and baroreceptor unloading using scanning laser-Doppler imaging; and (c) determine the role of nitric oxide (NO) in the control of active vasodilation by examining NO-dependent and independent changes in SkBF during hyperthermia using intradermal microdialysis. In addition, a fourth series of studies is proposed to quantify the upper limit of the prescriptive zone (ULPZ) and age-specific heat exchange coefficients in older versus younger healthy men and women during low-intensity activity. Data from this last proposed investigation operationalizes the SkBF decrement to allow policy-making by health organizations and for modeling biophysical and physiological responses of the elderly to extreme environments.

描述（改编自申请人的摘要）： 年龄65岁，非阿卡皮血流（SKBF）对高温的反应是 大大减弱。该年龄相关的缺陷的站点涉及 活性血管扩张器系统，一种非肾上腺素能传递途径 皮肤。提出的一系列研究将系统地检查潜力 衰老和积极影响的负面影响的机制 雌激素疗法被施加。在大小的男人和女人中 绝经后妇女接受各种激素替代疗法或无 治疗，PI计划（a）检查空间分布和异质性 主动皮肤血管舒张以确定功能的变化 毛细管丛密度和/或流动有助于SKBF的改变 使用扫描激光多普勒成像； （b）检查大小，空间 反射介导的去甲肾上腺皮质的分布和异质性 全身冷却期间的血管收缩和压力感受器卸载 扫描激光多普勒成像； （c）确定一氧化氮的作用（NO） 通过检查无依赖性和独立的活性血管舒张 使用皮内微透析在高温期间SKBF的变化。在 此外，提出了第四系列研究以量化 规定区（ULPZ）和特定年龄的热交换系数 在低强度活动中，年龄较大的男性和女性与年轻健康的男人和女性。数据 从最后提议的调查中，SKBF降低到 允许卫生组织制定决策，并为生物物理和 老年人对极端环境的生理反应。