EXERCISE TRAINING AND DEPRESSION IN OLDER ADULTS

老年人的运动训练和抑郁症

• 批准号: 6769406
• 负责人: James A Blumenthal
• 金额: $ 51.9万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6769406
• 关键词: antidepressants; baroreceptors; behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; cognition; disease /disorder classification; exercise; functional ability; group therapy; human old age (65+); human subject; human therapy evaluation; longitudinal human study; major depression; mental disorder chemotherapy; myocardial ischemia /hypoxia; neuropsychological tests; psychometrics; quality of life; relapse /recurrence; sertraline; vascular endothelium

Aging of the population and the increased prevalence of chronic diseases among the elderly are major challenges facing our society and medical community. More than 20% of Americans will experience an episode of depression serious enough to warrant diagnosis and treatment. Treatment of major depressive disorder (MDD) has focused on reduction of symptoms and restoration of functioning. Although antidepressant medication has been particularly effective in this regard, many patients either fail to respond to medication or suffer from significant side effects. Thus, there continues to be a need to identify alternative approaches for treating depression, particularly in the elderly. There is now good reason to believe that exercise may be one such approach. The study proposed in the application will build upon the applicant's previous work in which they demonstrated the feasibility and efficacy of exercise as a treatment for MDD in older men and women. The major aim of this project will be to test the hypothesis that a program of home exercise is as effective as supervised exercise and medication in reducing depression relative to placebo controls. As a further extension of past work, the Principal Investigator proposes to examine the differential effectiveness of exercise for a significant subgroup of patients identified by Magnetic Resonance Imaging of the brain as having "vascular depression." Two hundred sixteen men and women, aged > 55 years, with MDD will be randomly assigned to supervised exercise, home exercise, drug (sertraline), or placebo. Before and after treatment patients will undergo evaluation of depression and exercise testing, assessment of vascular functioning including endothelial dysfunction and baroreceptor control, and psychometric testing to assess cognitive function and other measures of quality of life. Six month follow-up will assess relapse rates. The data generated from this study will have important practical implications by determining the extent to which exercise may benefit older men and women with MDD. The study also will provide information regarding the relationship between vascular depression and various indices of vascular and neurocognitive function, and the extent to which these indices may be modifiable by treatment.

人口老龄化和慢性病患病率的增加 老年人之间的疾病是我们社会和医疗面临的主要挑战 社区。超过20％的美国人会经历抑郁症的情节 非常严重，可以保证诊断和治疗。专业的治疗 抑郁症（MDD）的重点是减轻症状和恢复 功能。尽管抗抑郁药特别是 在这方面有效，许多患者要么无法对药物做出反应，要么 遭受重大副作用。因此，仍然需要 确定治疗抑郁症的替代方法，特别是在 老年。现在有充分的理由相信锻炼可能是这样的 方法。申请中提出的研究将基于申请人的 他们证明了以前的工作 运动作为对年长男女的MDD的治疗。主要目的 项目将是检验以下假设，即家庭练习计划 在减少抑郁症亲戚的监督运动和药物方面有效 安慰剂控件。作为过去工作的进一步延长，校长 研究人员建议检查锻炼的差异效果 通过磁共振成像确定的大量患者亚组 大脑具有“血管抑郁症”。 26岁的男女，年龄> 55岁，与MDD一起随机 分配给有监督的运动，家庭运动，毒品（舍曲林）或安慰剂。 治疗前后患者将接受抑郁和 运动测试，评估血管功能，包括内皮 功能障碍和压力感受器以及心理测试测试以评估 认知功能和其他生活质量衡量标准。六个月的随访 将评估复发率。这项研究产生的数据将有 通过确定锻炼的程度来实现重要的实际含义 可能会使MDD老年男女受益。该研究还将提供 有关血管抑郁与各种关系之间关系的信息 血管和神经认知功能的指标以及这些索引的程度 指数可能可以通过治疗进行修改。

项目成果

Microvascular Endothelial Function and Neurocognition Among Adults With Major Depressive Disorder.

患有重度抑郁症的成人的微血管内皮功能和神经认知。

• DOI: 10.1016/j.jagp.2018.06.011
• 发表时间: 2018
• 期刊: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
• 作者: Smith,PatrickJ;Blumenthal,JamesA;Hinderliter,AlanL;Watkins,LanaL;Hoffman,BensonM;Sherwood,Andrew
• 通讯作者: Sherwood,Andrew

Intima-media thickness and age of first depressive episode.

• DOI: 10.1016/j.biopsycho.2008.11.001
• 发表时间: 2009-03
• 期刊: BIOLOGICAL PSYCHOLOGY
• 影响因子: 2.6
• 作者: Smith, Patrick J.;Blumenthal, James A.;Babyak, Michael A.;Doraiswamy, P. Murali;Hinderliter, Alan;Hoffman, Benson M.;Waugh, Robert;Sherwood, Andrew
• 通讯作者: Sherwood, Andrew

Is Exercise a Viable Treatment for Depression?

• DOI: 10.1249/01.fit.0000416000.09526.eb
• 发表时间: 2012-07
• 期刊: ACSM's health & fitness journal
• 作者: Blumenthal JA;Smith PJ;Hoffman BM
• 通讯作者: Hoffman BM

Exercise fails to improve neurocognition in depressed middle-aged and older adults.

• DOI: 10.1249/mss.0b013e31816b877c
• 发表时间: 2008-07
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1
• 作者: Hoffman BM;Blumenthal JA;Babyak MA;Smith PJ;Rogers SD;Doraiswamy PM;Sherwood A
• 通讯作者: Sherwood A

Exercise training and depression in older adults.

• DOI: 10.1016/j.neurobiolaging.2005.09.007
• 发表时间: 2005-12-01
• 期刊: Neurobiology of aging
• 影响因子: 4.2
• 作者: Barbour, Krista A;Blumenthal, James A
• 通讯作者: Blumenthal, James A