INDEPENDENT AND DEPENDENT LIFE IN THE ELDERLY

老年人的独立和依赖生活

• 批准号: 6168093
• 负责人: DAVID A. SNOWDON
• 金额: $ 90.18万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6168093
• 关键词: Alzheimer's disease; aging; apolipoproteins; cerebral cortex; clinical research; disease /disorder onset; disease /disorder proneness /risk; early experience; education; functional ability; genetic markers; head /neck injury; hippocampus; human old age (65+); human subject; human very old age (85+); language; lifestyle; longitudinal human study; memory; neuritic plaques; neurofibrillary tangles; neurons; prognosis; self care; synapses; vitamin B deficiency

DESCRIPTION (Adapted from Investigator's Abstract): This is an application for continuation of an existing study of the early, mid, and late-life factors contributing to the onset and course of Alzheimer's disease (AD). This research uses archival longitudinal data from a volunteer sample of N=678 Catholic Nuns, aged 75 to 103 (in 1991). The investigators seek to continue the evaluation of this cohort for risk factors for Alzheimer's disease (AD) until the year 2001. The proposal seeks to substantiate preliminary findings that AD is not an inevitable consequence of biologic aging and that AD is related to early life factors, and analyzes the effects of genetic markers and other, later risk factors for AD.

描述（根据调查员的摘要改编）：这是一个应用程序 为了继续对早期，中期和晚期的现有研究 导致阿尔茨海默氏病（AD）发作和进程的因素。 本研究使用档案纵向数据来自志愿者样本 n = 678个天主教修女，年龄75至103（1991年）。 调查人员寻求 继续评估这一对阿尔茨海默氏症风险因素的队列 疾病（AD）直到2001年。该提案旨在证实 初步发现AD不是生物学的必然结果 衰老和广告与早期生命因素有关，并分析影响 遗传标记和其他AD的危险因素。