EPIDEMIOLOGY OF AGING AND ALZHEIMER'S DISEASE

衰老和阿尔茨海默病的流行病学

• 批准号: 3070613
• 负责人: DAVID A. SNOWDON
• 金额: $ 6.47万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-01-27 至 1996-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3070613
• 关键词: Alzheimer's disease; aging; atherosclerosis; cerebrovascular disorders; cognition; data collection; disease /disorder proneness /risk; education; emotional dependency; epidemiology; family; functional ability; genetic disorder; histopathology; human old age (65+); human tissue; neurophysiology; postmortem; questionnaires; self help; socioeconomics

The focus of the candidate's research program for this Research Career Development Award proposal is the study of aging and Alzheimer's disease. The study population is 1,975 Roman Catholic sisters (nuns) who were born before 1917. Archival records will be used to reconstruct early life traits such as socioeconomic and health status of the family, cognitive ability, and attained education. About 760 of the 1,975 sisters survived to 1991 (ages 75 to 100) and will participate in annual assessments of mental and physical function. Data from the archives and annual assessments will be used to determine the relation of early life traits of life expectancy and the duration of "independent" life (able to perform self-care) and "dependent" life (unable to perform self-care). The supplemental project will examine the relation of Alzheimer's disease (AD) occurrence to both the familial and cognitive traits of early life and the pathophysiologic and cognitive characteristics of late life. These late-life characteristics include cerebrovascular atherosclerosis and its risk factors, cognitive ability, and functional brain reserve (e.g., quantity of neurons and synapses, density of senile plaques, area and location of brain infarctions, and traits of early life are associated with AD because of their relationship to functional brain reserve. We propose that diminished functional brain reserve lowers the threshold of susceptibility to AD (symptoms of Ad appear during early neuropathological stages of the diseases). Participants in this study will be from the same defined population who range from 75 year-olds who were severely demented and disabled when they died to 100 year-olds who were highly functional when they died. Each participant (and brain) has a rich source of archival data covering social, familial, cognitive, functional, and health characteristics for the entire life span. Participants are homogenous on a multitude of adult traits that usually confound non-experimental studies, such as smoking, drinking, reproductive history, and access to health care. To date, over 90 percent of sisters invited to volunteer for the study have signed consent forms (indicating a willingness to participate in all phases of the study including brain donation). Overall, this is a well defined, cooperative, and closed population in which to examine the early and late life correlates of dementia, disability, and death. Adding a biomedical supplement to the ongoing social and behavioral study is an economical method of tapping a unique resource for Alzheimer's disease research.

该研究生涯的候选人研究计划的重点 发展奖提案是对衰老和阿尔茨海默氏病的研究。 研究人群是1,975个罗马天主教姐妹（修女） 1917年之前。档案记录将用于重建早期生活 家庭的社会经济和健康状况等特征，认知 能力并获得教育。 1,975个姐妹中约有760个幸存 到1991年（75至100岁），将参加年度评估 精神和身体机能。 来自档案和年度的数据 评估将用于确定早期生命特征的关系 预期寿命和“独立”生活的持续时间（能够表演 自我保健）和“依赖”生活（无法执行自我保健）。 补充项目将检查阿尔茨海默氏病的关系 （AD）出现早期生活的家族和认知特征 后期生活的病理生理和认知特征。 这些 晚期的特征包括脑血管骨膜硬化及其 风险因素，认知能力和功能性大脑储备（例如， 数量的神经元和突触，老年斑块的密度，区域和 大脑梗塞的位置和早期的特征与 广告是因为它们与功能性大脑储备的关系。 我们建议 功能性大脑储备降低了降低的阈值 对AD的敏感性（AD的症状出现在早期神经病理学期间 疾病的阶段）。 这项研究的参与者将来自同一定义的人群 范围从75岁的年龄段，他们在严重痴呆和残疾时 死于100岁的年轻人，他们去世后具有高度功能。 每个 参与者（和大脑）拥有丰富的档案数据来源，涵盖了社交， 整个家族，认知，功能和健康特征 寿命。 参与者对许多成人特征是同质的 通常会混淆非实验研究，例如吸烟，饮酒， 生殖历史和获得医疗保健。 迄今为止，超过90％ 被邀请参加该研究的姐妹的签署同意书 （表明愿意参与研究的所有阶段 包括大脑捐赠）。 总体而言，这是一个明确的，合作的， 和封闭的人口来检查早期和晚期 痴呆，残疾和死亡的相关性。 添加生物医学 对正在进行的社会和行为研究的补充是经济的 利用阿尔茨海默氏病研究的独特资源的方法。