DISCRIMINATION OF ABUSED DRUG MIXTURES

对滥用药物混合物的歧视

基本信息

批准号：
6175111
负责人：
IAN P STOLERMAN
金额：
$ 10.75万
依托单位：
UNIVERSITY OF LONDON INST OF PSYCHIATRY
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-09-01 至 2002-09-30
项目状态：
已结题

项目摘要

DESCRIPTION: (Applicant's Abstract) The aims are to explore behavioral effects of some abused drug mixtures, to use recently developed methods to analyze discriminative effects of single drugs with multiple effects, and to explore the potential of Occasion Setting in relation to drug action. Both mixtures of drugs and single substances with multiple effects will be analyzed as compound interoceptive stimuli, bringing to drug action the theoretical framework of associative learning that is more commonly used in studies of compound exteroceptive stimuli. The emphasis will be upon mixtures of which one component is an opioid, notably mixtures of heroin plus cocaine ("speedballs") and of pentazocine plus tripelennamine ("T's & blues"). Experiments will use methods developed previously in the project: [1] the AND-discrimination procedure will provide sensitive measures for detecting interactions between drugs in mixtures and [2] the AND-OR discrimination procedure will be used to enhance the pharmacological specificity of stimuli produced by mixtures. The first experiments on Occasion Setting with drugs in two-lever paradigms will be carried out. The specificity of discriminative stimuli produced by mixtures of abused substances such as heroin plus cocaine will be evaluated in tests with pharmacologically similar drugs and drug mixtures, and with compounds from other pharmacological classes. Similarities and differences between different abused and non-abused mixtures will be determined to identify the key drug actions responsible for the characteristic effects of the mixtures. These techniques will be used to analyze in greater depth than previously the discriminative effects of single opioid drugs with multiple effects; the mixed agonist-antagonist opioids cyclazocine, pentazocine, buprenorphine and butorphanol may produce their characteristic effects and patterns of abuse through different profiles of effects across m- and k-opioid, NMDA and s receptors. Cyclazocine will be a reference drug and experiments with it will be primarily to standardize methods; the other mixed agonist-antagonists have different, less well-understood effects and neuropharmacological actions, but are of greater present-day clinical significance. Profiles of effects of these drugs will be examined for their intrinsic importance and to inform studies on their actions in mixtures with tripelennamine and cocaine.

描述：（申请人的摘要）目的是探索一些滥用药物混合物的行为影响使用最近开发的方法来分析单个的歧视效应具有多种作用的药物，并探索有可能的潜力与毒品作用有关的设置。两种药物的混合物和单一混合物具有多种作用的物质将被分析为复合感受性的刺激，使毒品行动成为关联的理论框架在复合外部感受的研究中更常用的学习刺激。重点将是一个组件是一个组件的混合物阿片类药物，尤其是海洛因的混合物加可卡因（“快球”）和 Pentazocine Plus Tripelennamine（“ T's＆Blues”）。实验将使用先前在项目中开发的方法：[1]和歧视程序将提供对检测相互作用之间相互作用的敏感措施混合物中的药物和[2]将使用和歧视程序为了增强混合物产生的刺激的药理特异性。有时用两杆范式的药物设置的第一个实验将进行。由将评估滥用物质（例如海洛因加可卡因）的混合物在药理上相似的药物和药物混合物的测试中，以及其他药理学类别的化合物。相似性和差异在不同的受虐待和未虐待的混合物之间将确定确定负责造成特征影响的关键毒品行动混合物。这些技术将用于更深入地分析比以前的单一阿片类药物的歧视作用多重影响；混合激动剂 - 抗抗原剂的阿片类药物环虫菌素，五唑胺，丁丙诺啡和丁苯酚可能会产生其特征通过各种效果的效果和虐待模式 M-和K-阿片类药物，NMDA和S受体。环虫菌将成为参考药物实验将主要是为了标准化方法。另一个混合的激动剂 - 抗逆邦剂具有不同的，不太理解的效果，并且神经药物的作用，但现在的临床更大意义。这些药物的作用概况将检查其内在的重要性，并为他们在混合物中的作用提供研究 Tripelennamine和可卡因。