DISCRIMINATION OF ABUSED DRUG MIXTURES

对滥用药物混合物的歧视

• 批准号: 3211942
• 负责人: IAN P STOLERMAN
• 金额: $ 4.05万
• 依托单位: UNIVERSITY OF LONDON
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3211942
• 关键词: amphetamines; antihistamines; behavior test; caffeine; combination chemotherapy; discrimination learning; dosage; drug abuse; drug addiction; drug metabolism; drug receptors; laboratory rat; morphine; operant conditionings; pentazocine; pentobarbital; phencyclidine; psychopharmacologic agent; psychopharmacology

THE DISCRIMINATION OF ABUSED DRUG MIXTURES The main aim is to explore the value, for the study of drug abuse, of a recent advance in drug discrimination methodology. Existing, well-developed methods for studying the discriminative stimulus effects of drugs focus almost exclusively on single drugs, whereas the abuse of mixtures of more than one drug at a time is a widespread health problem. A supplementary aim is to clarify understanding of the effects of single drugs with multiple effects; such drugs may be discriminated on the basis of a stimulus complex consisting of two or more components and the work will clarify ways in which such compound, interoceptive stimuli are processed. The novel approach proposed is based on methods for examining discriminative stimulus effects of drug mixtures in rats. Some basic principles underlying discrimination of mixtures have been evaluated in recent experiments with mixtures of nicotine and a benzodiazepine. In the work proposed, the discriminative stimulus effects of three different, abused mixtures will be examined: (1) amphetamine plus pentobarbital; (2) caffeine plus phenylpropanolamine; (3) pentazocine plus tripelennamine. Different groups of rats will be trained to discriminate each mixture, using two-bar, operant conditioning techniques. The ratios of doses of constituent drugs in the main experiments will be based on results of studies where effects of altering the dose-ratio will be studied systematically. The project will determine whether the effects of each of the three mixtures are perceived as the sum of their components, or whether distinctive, novel stimuli are generated. Characteristics, including specificity, of discriminative stimuli based on the three mixtures will be evaluated in generalization tests with the constituent drugs, with pharmacologically similar drugs, and with unrelated compounds. Control data will be obtained from rats trained to discriminate each of the constituent drugs of the mixtures. The information gained will aid the making of decisions on availability of some of the drugs and will provide a sounder pharmacological basis for treating abuse of mixtures.

滥用药物混合物的歧视 主要目的是探索对药物滥用研究的价值， 最近在药物歧视方法方面的进步。 现存的， 开发的方法用于研究歧视性刺激 药物的作用几乎只关注单一药物，而 一次滥用混合物一次以上药物是 广泛的健康问题。 补充目的是澄清 了解具有多种影响的单一药物的影响； 这样的药物可能会根据刺激进行区分 由两个或多个组成部分组成的复合物，工作将 澄清这种化合物，感知性刺激的方法 处理。 提出的新方法是基于 检查药物混合物中的歧视性刺激作用 老鼠。 混合物歧视的一些基本原则 在最近的混合物中已经评估了 尼古丁和苯二氮卓。 在提议的工作中， 三种不同的滥用的歧视性刺激效应 将检查混合物：（1）苯丙胺加五叶骨； （2）咖啡因加苯丙醇胺； （3）Pentazocine Plus Tripelennamine。 不同组的大鼠将接受训练 使用两杆操作调节来区分每种混合物 技术。 主要药物剂量的比率 实验将基于研究结果 改变剂量比率将被系统地研究。 项目 将确定三种混合物的影响是否 被视为其组件的总和，或者是否 产生独特的新型刺激。 特征， 包括特异性，基于三个 将在概括测试中评估混合物 具有药理学类似药物的组成药物，并且 无关化合物。 控制数据将从大鼠获得 经过训练以区分每种组成药物 混合物。 获得的信息将有助于做出决定 关于某些药物的可用性，将提供一个声音 治疗混合物滥用的药理基础。