OBESITY PREV AMONG PREPUBERTAL AFRICAN AMERICAN GIRLS

青春期前非洲裔美国女孩的肥胖问题

• 批准号: 6185191
• 负责人: Tom Baranowski
• 金额: $ 46.8万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6185191
• 关键词: African American; Internet; adipose tissue; behavior therapy; behavioral /social science research tag; bioenergetics; body physical activity; body weight; case history; child (0-11); clinical research; cooperative study; diet; disease /disorder proneness /risk; family genetics; family structure /dynamics; female; human subject; human therapy evaluation; nutrition related tag; obesity; outcomes research; phenotype

Obesity is a risk factor for several adult chronic diseases. Obesity is more prevalent among African-Americans (AA) than other ethnic groups, especially AA females. Obesity tracks from childhood into the adult years. Children above the 50th percentile (50 percent tile) and/or who have one or two obese parents are more likely to become obese than others. Thus, intervening just before and early in puberty among those at high risk may prevent obesity among those not already obese, and prevent or minimize further weight gain among those already overweight and lower chronic disease burden. We hypothesize that participation in 60 min or more per day of moderate to vigorous physical activity, eating 5 or more servings of fruit, juice and vegetables (FJ and V) per day, and decreasing dietary fat intake will minimize weight gain over a two year period among prepubertal 8-year-old (yo) AA girls in the upper 50 percent tile of BMI or who have one or more obese parents. Behavioral objectives will be achieved through a 2-year intervention consisting of a four-week summer day camp and a 23 month child-parent weekly interactive Fun, Food and Fitness web site to learn about healthy eating and physical activity. This study will employ a randomized two group (treatment-control) design with four annual repeated measures at baseline, mid program (+12 mo), post program (+24 mo), and a year after the program(+36 mo) starting with 336 girls. The primary intervention outcomes will be body weight and fat gain as measured by DEXA; secondary outcomes include cardiovascular disease risk factors, energy expenditure measured by doubly labeled water, dietary practices and psychosocial variables. Candidate gene polymorphisms and resting metabolic rate will be examined for association with obesity related phenotypes and response to intervention. Prior to the Intervention (Phase I) we will initiate three studies: 1) test of the validity of two alternative approaches to self-report of physical activity (24-hour physical activity recall vs. week activity recall); 2) assessment of family and personal factors that influence physical activity among these girls; and 3) development and pilot testing of a culturally sensitive month-long summer camp and two month world wide web program to help 8yo AA girls change their dietary and physical activity practices. This will be the first obesity prevention project to employ a month-long summer camp, web technology, and sophisticated biological measures to assess factors predictive of body composition change.

肥胖是几种成年慢性疾病的危险因素。在非裔美国人（AA）中，肥胖比其他族裔，尤其是AA女性更为普遍。 肥胖从童年到成人年。 高于第50个百分位数（瓷砖50％）和/或拥有一两个肥胖父母的儿童比其他孩子更有可能变得肥胖。 因此，在尚不肥胖的人的肥胖症中，在青春期前后，在青春期前后进行介入，并预防或最大程度地减少已经超重和降低慢性病负担的肥胖症。 我们假设在每天60分钟或以上进行中等至剧烈的体育锻炼，每天吃5份或更多份水果，果汁和蔬菜（FJ和V），减少饮食脂肪的摄入量将最大程度地减少在BMI或更多或更多肥胖的BMI或更多肥胖症中的50％tile tile of BMI或更多肥胖症中的50岁小女孩中的两年中的体重增加。 行为目标将通过2年的干预措施来实现，包括为期四周的夏季营地和23个月的儿童互动互动娱乐，食物和健身网站，以了解健康饮食和体育锻炼。 这项研究将采用一个随机的两组（治疗控制）设计，在基线，中期计划（+12 MO），POST PROPON（+24 MO）和该计划（+36 MO）之后的一年（+36 MO）开始，从336名女孩开始，在基线，MID计划（+12 MO），后期计划（+12 MO），使用四个年度重复措施。 DEXA测量的主要干预结果将是体重和脂肪增加。次要结果包括心血管疾病的危险因素，通过双重标记的水衡量的能量支出，饮食实践和社会心理变量。 候选基因多态性和静息代谢率将检查与肥胖相关表型和对干预措施的反应相关。 在干预之前（第一阶段），我们将启动三项研究：1）两种自我报告的替代方法的有效性测试（24小时的体育活动回顾与周的活动回忆）； 2）评估影响这些女孩体育锻炼的家庭和个人因素； 3）对文化敏感的一个月夏令营和两个月的全球网络计划的开发和试点测试，以帮助8yo AA女孩改变饮食和体育锻炼的实践。 这将是第一个采用长达一个月的夏令营，网络技术和复杂生物学测量的预防肥胖项目，以评估预测身体成分变化的因素。