COMPUTER MODEL OF HUMAN SUBSTRATE METABOLISM

人体底物代谢的计算机模型

• 批准号: 6033253
• 负责人: JEAN-PIERRE FLATT
• 金额: $ 6.52万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6033253
• 关键词: bioenergetics; body composition; body physical activity; carbohydrate metabolism; computer program /software; computer simulation; diet; exercise; glucose metabolism; mathematical model; metabolism; model design /development; nutrient intake activity; nutrition related tag

Variations in daily food intake are quite large in free-living individuals and not well synchronized with variations in energy expenditure (EE). Although this leads to substantial short-term energy imbalances, long-term errors in the energy balance are generally remarkably small (e.g. <1 to 2% of energy turnover over a year). Because changes in EE elicited by food intake attenuate only slightly the impact of over- or under-eating, weight maintenance depends primarily on appropriate adjustment of food intake to EE. The body's glycogen reserves are not much greater than the amount of carbohydrate (CHO) habitually consumed in one day. Evolution was therefore compelled to develop regulatory features giving specially high priority to the maintenance of CHO balance. An important issue in understanding body weight regulation when access to food is unrestricted, is whether maintenance of stable glycogen reserves is achieved merely through adjustment of glucose oxidation to CHO intake, or whether this may be helped by influences induced by changing glycogen levels on food intake. However, given the loose control of daily energy intake and balance, it is difficult to establish whether this, and/or other mechanisms are involved in bringing about appropriate "corrective changes" beta in food intake. To gain some insight about these difficulties, the development of a computer model of human energy metabolism was undertaken. It uses the Systems Dynamics approach in which changes in the content of various compartments are computed over consecutive time intervals. The course of events can be displayed in tables and graphs as a function of time, over hours, or hundreds of days. When conditions are kept constant, the simulations lead in time to steady-states; if aberrant configurations are reached, they suggest the changes which need to be implemented in the model to make it progressively more consistent with current knowledge of substrate metabolism in man. This grant application seeks funds to pursue the development of the current computer model, notably to construct it by integration of subsystems reflecting substrate metabolism in the body's major organs. In time, a user-friendly interface will be developed enabling investigators, students, dieticians, nutritionists and others to have an interactive opportunity to obtain an image of substrate metabolism in man and to observe its responses, including body weight changes, to conditions which can be specified by the user.

在自由生活的个体中，每日食物摄入量的变化很大，并且与能量消耗（EE）的变化没有很好地同步。尽管这导致了大量的短期能源失衡，但能量平衡的长期错误通常很小（例如一年内能量转换的1％至2％）。 由于食物摄入量引起的EE的变化仅略微减弱了过度或不足的影响，因此体重维持主要取决于对EE的适当调整食物摄入量。人体的糖原储量不比一天习惯食用的碳水化合物（CHO）量大。 因此，进化被迫开发监管特征，使其特别高于选择选择平衡的优先级。 当不受限制地使用食物时，了解体重调节体重的一个重要问题是，是否仅通过调整葡萄糖氧化以摄入CHO摄入量来维持稳定的糖原储量，或者是否通过因食物摄入量的变化糖原水平而引起的影响会有所帮助。 但是，鉴于对每日能量摄入和平衡的控制宽松，很难确定这是否和/或其他机制在带来适当的“纠正性更改”β中的β中涉及。为了了解这些困难，开发了人类能源代谢的计算机模型。 它使用系统动力学方法，其中在连续时间间隔内计算各个隔室内容的变化。 事件的过程可以随时间，数小时或数百天的时间在表和图中显示。 当保持条件恒定时，模拟会导致稳态。如果达到异常配置，他们建议需要在模型中实施的更改，以使其与人类中底物代谢的当前知识逐渐一致。该赠款应用程序寻求资金来追求当前计算机模型的开发，特别是通过整合反映人体主要器官中底物代谢的子系统来构建它。 随着时间的流逝，将开发一个用户友好的界面，使研究人员，学生，营养师，营养学家和其他人有互动的机会，以获取人类中底物代谢的形象，并观察其反应，包括体重的变化，对用户可以指定的条件。