E-Risk Longitudinal Twin Study age-30 follow-up: a unique resource for studying mental health, adversity & prosperity over the first 3 decades of life

E-Risk 纵向双胞胎研究 30 岁随访：研究心理健康、逆境的独特资源

• 批准号: MR/X010791/1
• 负责人: Helen Fisher
• 金额: $ 297.43万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX010791%2F1
• 关键词: Risk; Longitudinal; Twin; Study; age

CONTEXT: The twenties are an important developmental period in which individuals traditionally become fully independent of their parents, complete their education, enter the workforce/housing-market, and develop stable relationships. How individuals navigate this early adulthood period will determine their health, well-being, and economic prosperity in mid-life. Unfortunately, the twenties are also the peak age for mental health problems, which can derail these key developmental tasks. The triple shocks of Brexit, the COVID-19 pandemic, and the transition to a Net Zero future have resulted in major societal changes and economic instability - we do not know how this will affect the mental health and prospects of young adults nor what will influence whether they falter or prosper. Therefore, we propose to assess young adults at the end of their twenties to capture the factors that may influence these different outcomes so that researchers and practitioners can explore how best to support the most vulnerable young adults to thrive in these unprecedented times, and ultimately influence policy.AIMS: This infrastructure funding bid aims to collect new data from twin participants of the Environmental Risk (E-Risk) Longitudinal Twin Study when they are 30 years old. The three decades worth of comprehensive clinical-quality data, genetic and biological stress markers, and linked administrative records will then be made freely and widely accessible to the research community.METHOD: We will capitalise upon the E-Risk Longitudinal Twin Study, a cohort of 2232 twins born in England and Wales in 1994-1995 who have completed extensive home-visit assessments (including on mental health, social experiences, deprivation, educational attainment, and provided biological samples) at 5, 7, 10, 12 and 18 years of age (when 93% of the twins were seen). This cohort is unique as study members are spread among poor (n=900), comfortably-off (n=700), and wealthier (n=600) families, allowing researchers to compare the outcomes of these groups. For this project we propose to collect new data on the twins when they are 30 years old in 2024-2025. This will involve remote assessments by trained researchers over Zoom on mental health, adverse life experiences, human-capital-building behaviours, social and economic outcomes, and potential protective factors. We will capture their quality of life and expectations about the future and social mobility via a tool developed by young adults with lived experience of mental health issues. A nurse will visit participants at home to collect a blood sample, and we will link data to their health, welfare, education, crime, social media, and geographical records. This updated dataset will be made freely available and widely accessible to researchers across the UK and globally. We will publicise this resource through webinars, journal papers, and websites, and create training videos to support researchers to access and use this data. Additionally, our young-adult advisors will produce a priority list of questions for researchers to answer with the E-Risk dataset.BENEFITS: This project will provide a unique resource for researchers to conduct genetically informed investigations of how mental health problems, biological factors, social inequality and adversity in the first two decades of life shape variation in mental health, pace of aging, relationships/connectedness, trust, future expectations/aspirations, and prosperity in the third decade of life. Such research will provide important insights into which factors lead to young adults faltering or prospering in this period of social and economic turmoil. These insights are crucial to inform policy, practice, and societal responses to support young adults to thrive in these unprecedented times. Increasing the number of young adults who are mentally healthy and socially mobile in mid-life could ultimately boost the UK economy and reduce strain on the NHS.

背景：二十多岁是一个重要的发展时期，传统上，个人完全独立于父母，完成教育，进入劳动力/住房市场并发展稳定的关系。个人如何在这个成年初期导航将决定中年的健康，福祉和经济繁荣。不幸的是，二十年代也是精神健康问题的高峰时代，这可能会使这些关键的发展任务脱轨。英国脱欧，共同-19大流行以及向零净未来的过渡导致了重大社会变化和经济不稳定的三重冲击 - 我们不知道这将如何影响年轻人的心理健康和前景，也不会影响他们是否会影响他们的繁荣或繁荣。因此，我们建议在二十多岁结束时评估年轻人，以捕获可能影响这些不同结果的因素，以便研究人员和实践者可以探索如何最好地支持最脆弱的年轻人在这些前所未有的时期蓬勃发展，并最终影响政策，并最终影响aim。 老的。三十年的全面临床质量数据，遗传和生物压力标志物以及链接的行政记录将被自由且广泛地访问研究社区。在5、7、10、12和18岁（当时看到93％的双胞胎）时，教育程度并提供了生物样品）。该队列是独一无二的，因为研究成员在贫穷（n = 900），舒适的（n = 700）和较富裕（n = 600）的家庭之间传播，从而使研究人员可以比较这些群体的结果。对于这个项目，我们建议在2024 - 2025年30岁时收集有关双胞胎的新数据。这将涉及训练有素的研究人员对精神健康，不良生活经历，人力资本构建行为，社会和经济成果以及潜在的保护因素的远程评估。我们将通过具有精神健康问题经验的年轻人开发的工具来捕捉他们对未来和社会流动性的期望。护士将拜访参与者在家收集血液样本，我们将数据与他们的健康，福利，教育，犯罪，社交媒体和地理记录联系起来。该更新的数据集将免费提供，并在英国和全球的研究人员中广泛使用。我们将通过网络研讨会，期刊论文和网站宣传此资源，并创建培训视频，以支持研究人员访问和使用此数据。此外，我们的年轻产顾问将为研究人员提供优先列表，以便研究人员回答电子风险数据集。BENEFITS：该项目将为研究人员提供独特的资源，使研究人员对精神健康问题，生物健康因素，社会不平等和逆境如何在头三十年中的繁荣/兴奋，未来，关系，关系，关系，连接，连接的繁荣时期的繁荣差异，对精神健康问题，社会不平等和逆境如何进行遗传知情研究，这是一个独特的研究。生活。这样的研究将提供重要的见解，以了解哪些因素导致年轻人在社会和经济动荡时期步履蹒跚或繁荣。这些见解对于在这些前所未有的时代为支持年轻人而壮成长的政策，实践和社会反应至关重要。增加在中年生活和社会流动性的年轻人的数量最终可以提高英国经济并减少NHS的压力。

项目成果

Problematic technology use and sleep quality in young adulthood: novel insights from a nationally representative twin study.

• DOI: 10.1093/sleep/zsad038
• 发表时间: 2023-06-13
• 期刊: Sleep
• 影响因子: 5.6

Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals.

跨国家和跨代证据表明，教育程度可能会减缓欧洲人后裔的衰老速度。

• DOI: 10.1093/geronb/gbad056
• 发表时间: 2023
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Sugden,Karen;Moffitt,TerrieE;Arpawong,ThalidaEm;Arseneault,Louise;Belsky,DanielW;Corcoran,DavidL;Crimmins,EileenM;Hannon,Eilis;Houts,Renate;Mill,JonathanS;Poulton,Richie;Ramrakha,Sandhya;Wertz,Jasmin;Williams,BenjaminS;C
• 通讯作者: C

Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts.

多基因指数是否捕获了对儿童外化行为的“直接”影响？

• DOI: 10.1101/2023.05.31.23290802
• 发表时间: 2023
• 期刊: the preprint server for health sciences
• 作者: Tanksley PT

Do Children With Attention-Deficit/Hyperactivity Disorder Symptoms Become Socially Isolated? Longitudinal Within-Person Associations in a Nationally Representative Cohort.

• DOI: 10.1016/j.jaacop.2023.02.001
• 发表时间: 2023-06
• 期刊: JAACAP open
• 作者: Thompson, Katherine N;Agnew-Blais, Jessica C;Allegrini, Andrea G;Bryan, Bridget T;Danese, Andrea;Odgers, Candice L;Matthews, Timothy;Arseneault, Louise
• 通讯作者: Arseneault, Louise

The socioeconomic consequences of loneliness: Evidence from a nationally representative longitudinal study of young adults

孤独的社会经济后果：来自全国代表性年轻人纵向研究的证据

• DOI: 10.1016/j.socscimed.2024.116697
• 发表时间: 2024
• 期刊: Social Science & Medicine
• 影响因子: 5.4
• 作者: Bryan B