E-Risk Longitudinal Twin Study age-30 follow-up: a unique resource for studying mental health, adversity & prosperity over the first 3 decades of life

E-Risk 纵向双胞胎研究 30 岁随访：研究心理健康、逆境的独特资源

基本信息

批准号：
MR/X010791/1
负责人：
Helen Fisher
金额：
$ 297.43万
依托单位：
King's College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FX010791%2F1
关键词：
Risk Longitudinal Twin Study age

项目摘要

CONTEXT: The twenties are an important developmental period in which individuals traditionally become fully independent of their parents, complete their education, enter the workforce/housing-market, and develop stable relationships. How individuals navigate this early adulthood period will determine their health, well-being, and economic prosperity in mid-life. Unfortunately, the twenties are also the peak age for mental health problems, which can derail these key developmental tasks. The triple shocks of Brexit, the COVID-19 pandemic, and the transition to a Net Zero future have resulted in major societal changes and economic instability - we do not know how this will affect the mental health and prospects of young adults nor what will influence whether they falter or prosper. Therefore, we propose to assess young adults at the end of their twenties to capture the factors that may influence these different outcomes so that researchers and practitioners can explore how best to support the most vulnerable young adults to thrive in these unprecedented times, and ultimately influence policy.AIMS: This infrastructure funding bid aims to collect new data from twin participants of the Environmental Risk (E-Risk) Longitudinal Twin Study when they are 30 years old. The three decades worth of comprehensive clinical-quality data, genetic and biological stress markers, and linked administrative records will then be made freely and widely accessible to the research community.METHOD: We will capitalise upon the E-Risk Longitudinal Twin Study, a cohort of 2232 twins born in England and Wales in 1994-1995 who have completed extensive home-visit assessments (including on mental health, social experiences, deprivation, educational attainment, and provided biological samples) at 5, 7, 10, 12 and 18 years of age (when 93% of the twins were seen). This cohort is unique as study members are spread among poor (n=900), comfortably-off (n=700), and wealthier (n=600) families, allowing researchers to compare the outcomes of these groups. For this project we propose to collect new data on the twins when they are 30 years old in 2024-2025. This will involve remote assessments by trained researchers over Zoom on mental health, adverse life experiences, human-capital-building behaviours, social and economic outcomes, and potential protective factors. We will capture their quality of life and expectations about the future and social mobility via a tool developed by young adults with lived experience of mental health issues. A nurse will visit participants at home to collect a blood sample, and we will link data to their health, welfare, education, crime, social media, and geographical records. This updated dataset will be made freely available and widely accessible to researchers across the UK and globally. We will publicise this resource through webinars, journal papers, and websites, and create training videos to support researchers to access and use this data. Additionally, our young-adult advisors will produce a priority list of questions for researchers to answer with the E-Risk dataset.BENEFITS: This project will provide a unique resource for researchers to conduct genetically informed investigations of how mental health problems, biological factors, social inequality and adversity in the first two decades of life shape variation in mental health, pace of aging, relationships/connectedness, trust, future expectations/aspirations, and prosperity in the third decade of life. Such research will provide important insights into which factors lead to young adults faltering or prospering in this period of social and economic turmoil. These insights are crucial to inform policy, practice, and societal responses to support young adults to thrive in these unprecedented times. Increasing the number of young adults who are mentally healthy and socially mobile in mid-life could ultimately boost the UK economy and reduce strain on the NHS.

背景：二十多岁是一个重要的发展时期，在这个时期，个人传统上完全独立于父母，完成学业，进入劳动力/住房市场，并发展稳定的关系。个人如何度过这个成年早期将决定他们中年时的健康、福祉和经济繁荣。不幸的是，二十多岁也是心理健康问题的高峰年龄，这可能会破坏这些关键的发展任务。英国脱欧、Covid-19大流行以及向净零未来过渡的三重冲击导致了重大社会变革和经济不稳定——我们不知道这将如何影响年轻人的心理健康和前景，也不知道什么会影响无论他们是衰弱还是繁荣。因此，我们建议对二十多岁的年轻人进行评估，以捕捉可能影响这些不同结果的因素，以便研究人员和从业者能够探索如何最好地支持最脆弱的年轻人在这个前所未有的时代茁壮成长，并最终影响政策.目的：这项基础设施资助投标旨在收集环境风险（E-Risk）纵向双胞胎研究的双胞胎参与者 30 岁时的新数据。然后，研究界将免费、广泛地获得价值三十年的综合临床质量数据、遗传和生物压力标记以及相关的管理记录。方法：我们将利用 E-Risk 纵向双胞胎研究，这是一个队列1994-1995 年出生于英格兰和威尔士的 2232 名双胞胎在 5 点完成了广泛的家访评估（包括心理健康、社会经历、贫困、教育程度并提供了生物样本）， 7、10、12 和 18 岁（93% 的双胞胎都是在这个时候看到的）。该队列的独特之处在于研究成员分布在贫困家庭 (n=900)、小康家庭 (n=700) 和富裕家庭 (n=600)，从而使研究人员能够比较这些群体的结果。对于这个项目，我们建议在 2024-2025 年这对双胞胎 30 岁时收集他们的新数据。这将涉及训练有素的研究人员通过 Zoom 对心理健康、不良生活经历、人力资本建设行为、社会和经济成果以及潜在的保护因素进行远程评估。我们将通过由具有心理健康问题经验的年轻人开发的工具来了解他们的生活质量以及对未来和社会流动性的期望。护士将拜访参与者家中采集血液样本，我们会将数据与他们的健康、福利、教育、犯罪、社交媒体和地理记录联系起来。该更新后的数据集将免费提供给英国和全球的研究人员并广泛使用。我们将通过网络研讨会、期刊论文和网站来宣传该资源，并制作培训视频以支持研究人员访问和使用这些数据。此外，我们的年轻成人顾问将制作一份优先问题清单，供研究人员使用 E-Risk 数据集回答。好处：该项目将为研究人员提供独特的资源，以对心理健康问题、生物因素、生命前二十年的社会不平等和逆境会影响生命第三个十年的心理健康、衰老速度、人际关系/联系、信任、未来期望/愿望和繁荣。此类研究将为了解哪些因素导致年轻人在这个社会和经济动荡时期陷入困境或繁荣提供重要见解。这些见解对于为政策、实践和社会应对措施提供信息至关重要，以支持年轻人在这个前所未有的时代茁壮成长。增加中年心理健康且具有社会流动性的年轻人数量最终可以提振英国经济并减轻国民医疗服务体系（NHS）的压力。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Problematic technology use and sleep quality in young adulthood: novel insights from a nationally representative twin study.

DOI：
10.1093/sleep/zsad038
发表时间：
2023-06-13
期刊：
Sleep
影响因子：
5.6
作者：
通讯作者：

Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals.

跨国家和跨代证据表明，教育程度可能会减缓欧洲人后裔的衰老速度。

DOI：
10.1093/geronb/gbad056
发表时间：
2023
期刊：
The journals of gerontology. Series B, Psychological sciences and social sciences
影响因子：
0
作者：
Sugden,Karen;Moffitt,TerrieE;Arpawong,ThalidaEm;Arseneault,Louise;Belsky,DanielW;Corcoran,DavidL;Crimmins,EileenM;Hannon,Eilis;Houts,Renate;Mill,JonathanS;Poulton,Richie;Ramrakha,Sandhya;Wertz,Jasmin;Williams,BenjaminS;C
通讯作者：
C

Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts.

多基因指数是否捕获了对儿童外化行为的“直接”影响？

DOI：
10.1101/2023.05.31.23290802
发表时间：
2023
期刊：
the preprint server for health sciences
影响因子：
0
作者：
Tanksley PT
通讯作者：
Tanksley PT

Do Children With Attention-Deficit/Hyperactivity Disorder Symptoms Become Socially Isolated? Longitudinal Within-Person Associations in a Nationally Representative Cohort.

DOI：
10.1016/j.jaacop.2023.02.001
发表时间：
2023-06
期刊：
JAACAP open
影响因子：
0
作者：
Thompson, Katherine N;Agnew-Blais, Jessica C;Allegrini, Andrea G;Bryan, Bridget T;Danese, Andrea;Odgers, Candice L;Matthews, Timothy;Arseneault, Louise
通讯作者：
Arseneault, Louise

The socioeconomic consequences of loneliness: Evidence from a nationally representative longitudinal study of young adults

孤独的社会经济后果：来自全国代表性年轻人纵向研究的证据