Developmental trajectories of psychosis in population-based samples: interplay between early adversity and familial risk

基于人群的样本中精神病的发展轨迹：早期逆境与家庭风险之间的相互作用

• 批准号: G1002366/1
• 负责人: Helen Fisher
• 金额: $ 35.15万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002366%2F1
• 关键词: Developmental; trajectories; psychosis; population; based

Mental health problems such as psychosis (e.g., schizophrenia) can be extremely disabling and result in massive costs for the individual, NHS services and society in general. Greater understanding of what factors are involved in development and persistence of such disorders would assist attempts to prevent and treat them. One of the major factors thought to cause psychosis is an individual‘s genetic make-up but environmental factors are also thought to play a role, possibly in combination with genes. Therefore, I propose to investigate whether individuals who have been exposed to potentially distressing experiences in childhood (severely beaten by or separated from their parents) and have a genetic risk (positive family history) are more likely to experience psychotic symptoms (such as hearing voices) over a long period of time and require treatment for psychosis during the life-course than individuals with only one or neither of these factors. To test this proposition I will analyse data from four different longitudinal studies: three general population birth cohorts in adolescence and adulthood and a 10-year follow-up of clinically diagnosed psychosis patients on whom information is available about their family and childhood history and experience of psychotic symptoms and mental health treatment at different time points.

精神疾病（例如精神分裂症）等精神健康问题可能会造成极大的残疾，并给个人、NHS 服务和整个社会带来巨大的损失，更好地了解此类疾病的发展和持续存在涉及哪些因素将有助于预防。并治疗他们，被认为是导致精神病的主要因素之一是个体的基因构成，但环境因素也被认为发挥了作用，可能与基因结合，因此，我建议调查个体是否接触过。可能令人痛苦童年经历（被父母严厉殴打或与父母分离）并且有遗传风险（阳性家族史）更有可能在很长一段时间内出现精神病症状（例如听到声音），并需要在一生中接受精神病治疗为了检验这个命题，我将分析来自四项不同纵向研究的数据：三个青春期和成年期的一般人群出生队列，以及对临床诊断的精神病患者的 10 年随访。信息是谁了解他们的家庭和童年史以及不同时间点的精神病症状和心理健康治疗的经历。