TRAF MOLECULES IN CELL SIGNALING

细胞信号转导中的 TRAF 分子

• 批准号: 6119593
• 负责人: KATHRYN R. ELY
• 金额: --
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6119593
• 关键词: biomaterials; proteins; structural biology

Cell signaling effected by tumor necrosis factor (TNF) is critical for a number for immune processes. The signal is triggered by binding of ligand to the TNF receptor at the cell surface and transmitted by molecules that bind the cytoplasmic portion of the TNF receptors. These binding proteins, called TRAFs, are novel proteins and their function is still being characterized. We have produced crystals of a TRAF molecule that diffract to high resolution and the crystals form in space group R32 with a=b=85 E, c=320 E. We plan to use MAD phasing to solve the structure.

受肿瘤坏死因子（TNF）产生的细胞信号传导至关重要 用于免疫过程的数字。 信号是通过绑定触发的 配体向TNF受体处于细胞表面，并通过 结合TNF受体的细胞质部分的分子。 这些被称为TRAF的结合蛋白是新型蛋白质及其 功能仍在表征。 我们已经产生了晶体 衍射到高分辨率和晶体形成的TRAF分子 在空间群R32中，a = b = 85 e，c = 320 E.我们计划使用疯狂的相相 解决结构。