SOLUTION STRUCTURE OF SERINE-RICH DOMAIN FROM CRK-ASSOCIATED SUBSTRATE

来自 CRK 相关底物的富含丝氨酸结构域的溶液结构

• 批准号: 7601710
• 负责人: KATHRYN R. ELY
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601710
• 关键词: Binding Sites; Cell Adhesion; Computer Retrieval of Information on Scientific Projects Database; Docking; Focal Adhesions; Funding; Grant; Institution; Oncogenic; Physiological; Play; Positioning Attribute; Proteins; Regulation; Reporting; Research; Research Personnel; Resources; Role; Serine; Signal Transduction; Solutions; Source; Structure; United States National Institutes of Health; migration; protein protein interaction; Binding Sites; Cell Adhesion; Computer Retrieval of Information on Scientific Projects Database; Docking; Focal Adhesions; Funding; Grant; Institution; Oncogenic; Physiological; Play; Positioning Attribute; Proteins; Regulation; Reporting; Research; Research Personnel; Resources; Role; Serine; Signal Transduction; Solutions; Source; Structure; United States National Institutes of Health; migration; protein protein interaction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 130cas (Crk-associated substrate) is a docking protein that is involved in assembly of focal adhesions and concomitant cellular signaling. It plays a role in physiological regulation of cell adhesion, migration, survival, and proliferation, as well as in oncogenic transformation. The molecule consists of multiple protein-protein interaction motifs, including a serine-rich region that is positioned between Crk and Src-binding sites. This study reports the first structure of a functional domain of Cas.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 130CA（与CRK相关的底物）是一种对接蛋白，与局灶性粘连和伴随的细胞信号传导有关。它在细胞粘附，迁移，生存和增殖以及致癌转化中起作用。该分子由多种蛋白质 - 蛋白质相互作用基序组成，包括位于CRK和SRC结合位点之间的富含丝氨酸的区域。这项研究报告了CAS功能域的第一个结构。