PHARMACOKINETICS OF ANTITUBERCULOUS AGENTS IN HIV INFECTION

HIV 感染中抗结核药物的药代动力学

• 批准号: 6115213
• 负责人: JOHN E CONTE
• 金额: $ 5.16万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115213
• 关键词: HIV infections; antitubercular agents; blood chemistry; bronchoscopy; clinical research; diagnostic respiratory lavage; ethambutol; human subject; isoniazid; oral administration; pharmacokinetics; pyrazinamide; respiratory pharmacology; rifamycins

Specific aims are to determine and compare: a) plasma pharmacokinetics of orally administered antituberculous agents, isoniazid, rifampin, pyrazinamide, ethambutol, + ethionamidein HIV+ & HIV- men & women, & b) intrapulmonary pharmacokinetics of these drugs by measuring drug concentrations in bronchoalveolar lavage fluid. This investigation consists of 5 studies (1 for each drug) involving 240 subjects. By performing bronchoscopy and bronchoalveolar lavage following last dose, intrapulmonary pharmacokinetics and serum concentrations will be compared.

具体目的是确定和比较：a）口服药代动力学的口服抗结核剂，异烟肼，利福平，吡嗪酰胺，乙吡二酰胺，ethambutol， + ethionamidein hiv +＆hiv +＆hiv-＆hiv-＆hiv-＆hiv-男性和女性和妇女，＆b）通过对这些药物的液压药物进行液压药物的测量药物， 这项研究由5项研究（每种药物1项）组成，涉及240名受试者。 通过进行最后剂量后的支气管镜检查和支气管肺泡灌洗，将比较肺内药代动力学和血清浓度。