INTESTINAL PERMEABILITY OF CYCLOSPORIN A

环孢菌素 A 的肠道渗透性

• 批准号: 6297158
• 负责人: GORDON L AMIDON
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297158
• 关键词: P glycoprotein; clinical research; cyclosporines; cytochrome P450; gastrointestinal absorption /transport; human subject; jejunum; membrane permeability; perfusion

The effective intestinal permeability (Peff) of cyclosporin A (CsA) and interindividual variability of CsA Peff will be determined in the upper jejunum of healthy volunteers by using a regional intestinal perfusion technique. The amount of P-glycoprotein and Cytochrome P450 IIIA4 (CYP3A4) in the intestine will be measured to examine the potential contribution of intestinal secretion and metabolism to the Peff of CsA.

环孢菌素 A (CsA) 的有效肠道通透性 (Peff) 和 CsA Peff 的个体差异将通过使用区域肠道灌注技术在健康志愿者的上空肠中测定。 将测量肠道中 P-糖蛋白和细胞色素 P450 IIIA4 (CYP3A4) 的量，以检查肠道分泌和代谢对 CsA Peff 的潜在贡献。