PELLET GASTRIC EMPTYING TEST (PGET)

颗粒胃排空试验 (PGET)

• 批准号: 6263667
• 负责人: GORDON L AMIDON
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6263667
• 关键词: clearance rate; clinical trials; dosage forms; gastrointestinal absorption /transport; human subject; noninvasive diagnosis; particle; stomach emptying

In order to evaluate the influence of particle size on gastric emptying this randomized four-way crossover trial will be conducted in 12 healthy volunteers. This study is designed to validate that marker drugs of different particle sizes can be used as to assess gastric emptying. This study utilizes a novel methodology which has potential for future application as a non-invasive method for measuring gastric emptying.

为了评估颗粒大小对胃排空的影响，这项随机四向交叉试验将在 12 名健康志愿者中进行。 本研究旨在验证不同粒径的标记药物可用于评估胃排空。 这项研究采用了一种新颖的方法，该方法有可能作为一种非侵入性测量胃排空的方法在未来应用。