INTESTINAL PERMEABILITY OF CYCLOSPORIN A

环孢菌素 A 的肠道渗透性

• 批准号: 6274746
• 负责人: GORDON L AMIDON
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274746
• 关键词: P glycoprotein; clinical research; cyclosporines; cytochrome P450; gastrointestinal absorption /transport; human subject; jejunum; membrane permeability; perfusion

The effective intestinal permeability (Peff) of cyclosporin A (CsA) and interindividual variability of CsA Peff will be determined in the upper jejunum of healthy volunteers by using a regional intestinal perfusion technique. The amount of P-glycoprotein and Cytochrome P450 IIIA4 (CYP3A4) in the intestine will be measured to examine the potential contribution of intestinal secretion and metabolism to the Peff of CsA.

环孢菌素 A (CsA) 和有效肠道通透性 (Peff) CsA Peff 的个体间差异将由上层确定 通过使用局部肠道灌注对健康志愿者的空肠进行观察 技术。 P-糖蛋白和细胞色素P450 IIIA4的量 （CYP3A4）在肠道中将被测量以检查潜力 肠道分泌和代谢对 CsA Peff 的贡献。