ENERGY EXPENDITURE AND BODY COMPOSITION IN PREPUBESCENT FEMALES

青春期前女性的能量消耗和身体成分

• 批准号: 6112833
• 负责人: REINALDO FIGUEROA-COLON
• 金额: $ 2.95万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6112833
• 关键词: adolescence (12-20); bioenergetics; body composition; body weight; caloric dietary content; case history; clinical research; clinical trials; female; human puberty; human subject; longitudinal human study; middle childhood (6-11)

Background: This proopsal builds on our current NIH-Clinical Investigator Award (CIA) study of energy expenditure (EE) and body composition in prepubertal, 5-10 year old females. This enables us to prospectively follow this group of children annually for 5 years to determine EE and body composition changes through puberty. We hypothesize that children with low total (resting and nonresting) EE and low rates of fat oxidation will predict relatively rapid weight gain during puberty. Objectives: 1) To examine prospectively the total EE (adjusted for body composition) and the rate of fat oxidation in children during different Tanner stages. 2) To examine the components of EE in children with more rapid weight gain and those with normal-weight gain during puberty. 3) To track in each child the variability in EE and fuel utilization during different Tanner stages. Design: In our ongoing NIH-CIA study, 56 normal-weight prepubertal girls have undergone assessment of EE, body composition, biochemical profiles, and physical activity. We propose to re-evaluate these children annually over a period of 5 years. Significance: This study should provide new insight into the contribution of variation in EE and body composition during different stages of puberty to long-term weight gain. Using state-of-the-art methods, this study will provide valuable information for understanding which factors predispose certain individuals to obesity during puberty. This information is essential to develop strategies for the prevention of obesity starting in childhood.

背景：这一主要的基于我们当前的NIH临床研究者奖（CIA）的能量支出研究（EE）和5-10岁女性的身体成分。 这使我们能够前瞻性地跟随这组儿童5年，以确定EE和身体成分通过青春期的变化。 我们假设总（静止和非静止）EE和低脂肪氧化速率的儿童预测青春期期间体重增加相对较快。 目标：1）在不同的制革厂期间，儿童的总EE（根据身体成分调整了）和脂肪氧化的速率。 2）检查体重增加更快的儿童EE的组成部分，青春期期间体重正常的儿童。 3）跟踪每个孩子的EE和燃料利用率的变异性。设计：在我们正在进行的NIH-CIA研究中，有56名正常体重青春期前女孩对EE，身体成分，生化特征和体育活动进行了评估。 我们建议在5年的时间内每年重新评估这些孩子。 意义：这项研究应提供新的见解，以了解在青春期不同阶段EE和身体组成对长期体重增加的贡献的贡献。 使用最先进的方法，本研究将提供有价值的信息，以了解哪些因素使某些人在青春期期间肥胖。 此信息对于从童年开始制定肥胖的策略至关重要。