ADOLESCENT COAS--A TWIN FAMILY DESIGN

青少年COAS——双胞胎家庭设计

• 批准号: 2894247
• 负责人: William R. True
• 金额: $ 44.3万
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2894247
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; family structure /dynamics; father child interaction; genetic susceptibility; human subject; mother child interaction; paternal behavior; pharmacogenetics; social adjustment; substance abuse epidemiology; twin /multiplet

APPLICANT'S ABSTRACT: The objective of this proposal is to study the impact of paternal alcoholism on outcomes and functioning of male and female adolescent offspring. This aim will be accomplished by comparing data on adolescent offspring of 878 twins who are either concordant or discordant for alcoholism. Twin family studies afford important design advantages: identical twins share all their genes and fraternal twins share half so that genetic contributions to the onset of alcoholism are enrolled. The first aim will determine whether and to what extent the offspring of alcoholic twins compared to the offspring of non-alcoholic twins differ in regard to; alcohol use and abuse, psychopathology, academic achievement, general psyhcosocial competence and family relationships assessed by structured interviews and questionnaires. Second, the study will be extended to a twin-family design by collecting information on biological mothers' alcohol use and relevant maternal and paternal psychopathology. This will clarify differences between the comparative functioning and outcome data for the offspring of alcoholic fathers and offspring of non-alcoholic fathers by examining the role of spousal/maternal effects and twin father psychopathology co-morbid with alcoholism. Maternal effects can be controlled, and analysees will be conducted to assess the role of assortative mating, the tendancy of alcoholic parents to marry each other. Third, in order to understand the mechanisms whereby paternal alcoholism may impact offspring, three mediation models for familial transmission of alcoholism will be tested: deviant socialization, negative affect regulation and pharmacological vulnerability. This proposed research makes use of a unique resource because the twin fathers are all members of the Vietnam Era Twin Registry and have all participated in previous waves of data collection. While the offspring of these fathers are still adolescents, invaluable diagnostic, demogrphic and behavioral data have allowed us to characterize independent variables such as fathers' drinking history, psychopathology, and demographic variables such as income and education and family composition. Therefore, the proposed research gains the advantage of being a second wave investigation in which maximally informative families have already been ascertained.

申请人摘要：该提案的目的是研究影响 父亲酗​​酒对男性和女性的结果和功能的影响 青春期的后代。 这一目标将通过比较数据来实现 878 对双胞胎的青春期后代，要么一致，要么不一致 对于酗酒。 双胞胎家庭研究具有重要的设计优势： 同卵双胞胎共享所有基因，异卵双胞胎共享一半基因，因此 登记了酗酒发病的遗传因素。 第一个 目标将决定酒精的后代是否以及在何种程度上 双胞胎与非酗酒双胞胎的后代相比，在以下方面有所不同； 酒精使用和滥用、精神病理学、学术成就、一般 通过结构化评估的心理社会能力和家庭关系 访谈和问卷调查。 其次，研究范围将扩大到 通过收集亲生母亲的酒精信息进行双胞胎家庭设计 使用和相关的母亲和父亲精神病理学。 这将澄清 比较功能和结果数据之间的差异 酗酒父亲的后代和非酗酒父亲的后代 检查配偶/母亲影响和双胞胎父亲的作用 精神病理学与酗酒共病。 母体效应可以是 受控，并将进行分析以评估其作用 选型交配，酗酒的父母倾向于互相结婚。 第三，为了了解父亲酗酒的机制 影响后代，家庭传播的三种中介模型 酗酒将受到考验：异常的社交、负面影响 调节和药理脆弱性。 这项拟议的研究使得 使用独特的资源，因为双胞胎父亲都是组织的成员 越南时代双胞胎登记处并且都参加了前几波 数据收集。 虽然这些父亲的后代仍然 青少年，宝贵的诊断、人口统计和行为数据 使我们能够描述自变量，例如父亲的饮酒情况 历史、精神病理学和人口变量，例如收入和收入 教育和家庭构成。 因此，拟议的研究成果 作为第二波调查的优点是最大限度地 目前已确定知情家庭。