HCV TRANSMISSION: SEX, VIOLENCE ALCOHOL & DRUG USE

HCV 传播：性、暴力、酒精

• 批准号: 6174561
• 负责人: MARCIA RUSSELL
• 金额: $ 53.83万
• 依托单位: PACIFIC INSTITUTE FOR RES AND EVALUATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-20 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6174561
• 关键词: accident proneness; alcoholism /alcohol abuse; behavioral /social science research tag; clinical research; communicable disease transmission; disease /disorder proneness /risk; hepatitis C; hepatitis C virus; high risk behavior /lifestyle; human subject; polymerase chain reaction; sex behavior; substance abuse related behavior; violence

DESCRIPTION (adapted from the application) Disproportionate numbers of alcohol and drug users are infected with Hepatitis C virus (HCV). Although the majority of new cases appear to result from sharing contaminated drug paraphernalia, approximately 20% are attributed to sexual contact with an infected person. However, the HCV infectivity of semen and saliva is controversial. Based on evidence that alcohol and drug use are associated with high-risk sexual behavior (e.g., multiple sexual partners, a history of sexually transmitted diseases, and anal sex), violent behavior, and accidental injuries, we postulate that: 1) heavy drinking and other drug use increase HCV transmission via blood-to-blood contact in the context of sexual and other intimate interactions by promoting exposure to menstrual blood and bleeding caused by minor and major trauma and 2) heavy alcohol consumption may promote HCV transmission by depressing the immune system, increasing serum HCV RNA levels. We propose to assess lifetime and current drinking patterns, other drug use, and alcohol/drug-related behavior associated with possible blood-to-blood contact in the context of sexual, intimate situations in 16 STD clinic clients, 400 positive for anti-HCV and 1200 negative. Serum levels of HCV RNA will be assessed in anti-HCV+ clients by polymerase chain reaction. The relations between-alcohol/drug use and HCV status and the potential mediating effects of blood-to-blood contact related to high-risk sexual behavior, sexual victimization, domestic and other violence, accidental injuries, and unsafe drug use will be investigated us hierarchical regression analytic techniques; interaction terms will be used to investigate gender and racial differences in these relations. Cluster analysis will be employed to identify behavioral typologies associated with HCV status. Finally, the influence of lifetime and current drinking patterns on serum HCV RNA levels will be investigated, taking into account the effects of diet, smoking, and concomitant infections.

描述（根据应用程序改编） 不成比例的酒精和吸毒者感染了肝炎 C病毒（HCV）。尽管大多数新案件似乎是由于共享而造成的 受污染的药物用具，大约20％归因于性 与受感染者接触。但是，精液的HCV感染性 唾液是有争议的。基于证据表明酒精和吸毒是 与高风险的性行为相关（例如，多个性伴侣，一个 性传播疾病和肛交的历史），暴力行为和 意外伤害，我们假设：1）大量饮酒和其他药物使用 在性情况下，通过血流接触增加HCV的传播 和其他亲密互动，通过促进月经血液和 由小和重大创伤引起的出血以及2）大量饮酒可能 通过降低免疫系统来促进HCV传播，增加血清HCV RNA水平。 我们建议评估终身和当前的饮酒方式，其他药物使用， 和酒精/药物相关的行为与可能的血统相关 在16个性病诊所的性，亲密情况下接触， 400抗HCV阳性，为1200负。 HCV RNA的血清水平将是 通过聚合酶链反应在抗HCV+客户端评估。关系 酒精/药物使用和HCV状态以及潜在的介导作用 与高风险性行为，性行为有关的血液到血接触 受害，国内和其他暴力，意外伤害以及不安全 使用药物使用将研究美国分层回归分析技术； 互动术语将用于调查性别和种族差异 这些关系。聚类分析将用于识别行为 与HCV状态相关的类型。最后，一生的影响 将研究血清HCV RNA水平上的当前饮酒模式，采用 考虑到饮食，吸烟和伴随感染的影响。