Analyzing Lifetime Drinking Trajectories

分析终生饮酒轨迹

• 批准号: 6577071
• 负责人: MARCIA RUSSELL
• 金额: $ 15.24万
• 依托单位: PACIFIC INSTITUTE FOR RES AND EVALUATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6577071
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; antioxidants; behavioral /social science research tag; blood lipid; blood pressure; clinical research; disease /disorder proneness /risk; human data; interview; myocardial infarction; oxidative stress

DESCRIPTION (provided by applicant): Despite the critical impact that lifetime drinking patterns have on the development of alcohol disorders and chronic diseases, the challenges involved in their assessment and analysis have largely precluded their systematic study. To address this need, we developed a computer-assisted personal interview to assess lifetime drinking patterns, the Cognitive Lifetime Drinking History (CLDH), for use in the Center for Clinical and Medical Epidemiology of Alcohol from 1994 to 1999. However, only recently were statistical procedures and software developed for trajectory analysis that would allow us to fully examine data provided by the CLDH, taking changes in drinking patterns over time into consideration. This software provides procedures that can: (1) identify common patterns of change in alcohol consumption over a lifetime; (2) provide statistical tests of the adequacy of the reduced trajectories; and (3) provide statistical tests of the relations between the trajectories themselves and problem outcomes (Nagin, 1999). We propose to apply trajectory analysis to data from Center case-control studies of chronic disease and alcoholism to investigate lifetime drinking trajectories (LDTs), as follows: (1) normative LDTs (N=3637 controls); (2) LDTs and risk factors for chronic disease, i.e., blood pressure, oxidative stress, and blood lipids (controls only); (3) LDTs and myocardial infarction (N=3402, 707 cases, plus controls frequency matched for age, gender, county of residence); (4) LDTs among untreated and treated alcoholic populations (N=335); and (5) LDTs and recovery from alcoholism without treatment or entry into treatment. Currently, medical advice and guidelines for moderate drinking are based on epidemiological studies in which alcohol intake was measured at only one point in time, and few have considered drinking patterns. These studies will provide data for the first time on the relation of lifetime drinking patterns to long-term health outcomes. The majority of alcoholics never seek treatment. Although many eventually recover, the processes and consequences involved are poorly understood. The proposed studies have the potential to aid in assessing unmet needs for treatment, which problem drinkers are likely to benefit from brief interventions, and factors influencing treatment entry.

描述（由申请人提供）：尽管终生饮酒模式对酒精障碍和慢性疾病的发展具有至关重要的影响，但评估和分析中涉及的挑战在很大程度上阻碍了他们的系统研究。为了满足这一需求，我们开发了一种计算机辅助个人访谈来评估终生饮酒模式，即认知终生饮酒史 (CLDH)，供酒精临床和医学流行病学中心从 1994 年到 1999 年使用。为轨迹分析开发的统计程序和软件使我们能够充分检查 CLDH 提供的数据，同时考虑饮酒模式随时间的变化。该软件提供的程序可以：(1) 识别一生中饮酒量的常见变化模式； (2) 对简化轨迹的充分性进行统计检验； (3) 提供轨迹本身与问题结果之间关系的统计检验（Nagin，1999）。我们建议将轨迹分析应用于慢性病和酗酒中心病例对照研究的数据，以调查终生饮酒轨迹（LDT），如下：（1）规范LDT（N = 3637 对照）； (2) LDT和慢性病危险因素，即血压、氧化应激和血脂（仅限对照）； (3)LDTs和心肌梗死(N=3402，707例，加上与年龄、性别、居住县相匹配的对照频率)； (4) 未治疗和治疗的酗酒人群中的 LDT（N=335）； (5) LDT 和未经治疗或开始治疗的酗酒恢复。 目前，适量饮酒的医疗建议和指南都是基于流行病学研究，仅在一个时间点测量酒精摄入量，很少考虑饮酒模式。这些研究将首次提供有关终生饮酒模式与长期健康结果之间关系的数据。大多数酗酒者从不寻求治疗。尽管许多人最终康复了，但所涉及的过程和后果却鲜为人知。拟议的研究有可能有助于评估未满足的治疗需求，有问题的饮酒者可能会从简短的干预中受益，以及影响治疗进入的因素。