Analyzing Lifetime Drinking Trajectories

分析终生饮酒轨迹

• 批准号: 6577071
• 负责人: MARCIA RUSSELL
• 金额: $ 15.24万
• 依托单位: PACIFIC INSTITUTE FOR RES AND EVALUATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6577071
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; antioxidants; behavioral /social science research tag; blood lipid; blood pressure; clinical research; disease /disorder proneness /risk; human data; interview; myocardial infarction; oxidative stress

DESCRIPTION (provided by applicant): Despite the critical impact that lifetime drinking patterns have on the development of alcohol disorders and chronic diseases, the challenges involved in their assessment and analysis have largely precluded their systematic study. To address this need, we developed a computer-assisted personal interview to assess lifetime drinking patterns, the Cognitive Lifetime Drinking History (CLDH), for use in the Center for Clinical and Medical Epidemiology of Alcohol from 1994 to 1999. However, only recently were statistical procedures and software developed for trajectory analysis that would allow us to fully examine data provided by the CLDH, taking changes in drinking patterns over time into consideration. This software provides procedures that can: (1) identify common patterns of change in alcohol consumption over a lifetime; (2) provide statistical tests of the adequacy of the reduced trajectories; and (3) provide statistical tests of the relations between the trajectories themselves and problem outcomes (Nagin, 1999). We propose to apply trajectory analysis to data from Center case-control studies of chronic disease and alcoholism to investigate lifetime drinking trajectories (LDTs), as follows: (1) normative LDTs (N=3637 controls); (2) LDTs and risk factors for chronic disease, i.e., blood pressure, oxidative stress, and blood lipids (controls only); (3) LDTs and myocardial infarction (N=3402, 707 cases, plus controls frequency matched for age, gender, county of residence); (4) LDTs among untreated and treated alcoholic populations (N=335); and (5) LDTs and recovery from alcoholism without treatment or entry into treatment. Currently, medical advice and guidelines for moderate drinking are based on epidemiological studies in which alcohol intake was measured at only one point in time, and few have considered drinking patterns. These studies will provide data for the first time on the relation of lifetime drinking patterns to long-term health outcomes. The majority of alcoholics never seek treatment. Although many eventually recover, the processes and consequences involved are poorly understood. The proposed studies have the potential to aid in assessing unmet needs for treatment, which problem drinkers are likely to benefit from brief interventions, and factors influencing treatment entry.

描述（由申请人提供）：尽管终生饮酒方式对酒精疾病和慢性疾病的发展产生了关键的影响，但其评估和分析所涉及的挑战在很大程度上排除了他们的系统研究。为了满足这一需求，我们开发了一项由计算机辅助的个人访谈，以评估终身饮酒方式，即认知终生饮酒史（CLDH），用于1994年至1999年的酒精临床和医学流行病学中心。但是，直到最近才开发出用于培训的统计程序和软件，这些程序和软件将允许使用CLDH提供的数据量过多，从而使饮酒量过多地进行了对饮酒方式的全面研究，从而涉及饮酒方式。该软件提供可以：（1）确定一生中酒精消费变化的常见模式； （2）提供减少轨迹足够的统计检验； （3）提供有关轨迹本身与问题结果之间关系的统计检验（Nagin，1999）。我们建议将轨迹分析应用于中心病例对照研究的慢性疾病和酒精中毒的数据，以研究终生饮酒轨迹（LDTS），如下：（1）规范性LDTS（n = 3637个对照）； （2）慢性病的LDT和危险因素，即血压，氧化应激和血脂（仅对对照）； （3）LDT和心肌梗塞（n = 3402，707例，加上对年龄符合年龄匹配的频率，性别，居住县）； （4）未经处理和处理过的酒精种群中的LDT（n = 335）； （5）LDT和从酒精中毒中恢复，无需治疗或接受治疗。 当前，适度饮酒的医疗建议和准则是基于流行病学研究，其中仅在一个时间点测量酒精摄入量，很少有人考虑饮酒方式。这些研究将首次提供有关终身饮酒模式与长期健康结果的关系的数据。大多数酗酒者从不寻求治疗。尽管许多人最终康复，但所涉及的过程和后果知之甚少。拟议的研究有可能帮助评估未满足的治疗需求，这些问题饮酒者可能会从短暂的干预措施中受益以及影响治疗的因素。