PREVENTION OF NEUROMOTOR DEFICITS WITH CHELATION THERAPY

通过螯合疗法预防神经运动缺陷

• 批准号: 6164618
• 负责人: AMIT BHATTACHARYA
• 金额: $ 27.68万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6164618
• 关键词: age difference; balance; blood chemistry; chelating agents; chelation therapy; child (0-11); child psychology; clinical research; clinical trials; cognition; drug screening /evaluation; gait; gender difference; human subject; human therapy evaluation; intelligence tests; lead poisoning; longitudinal human study; neuromuscular disorder chemotherapy; neuromuscular function; neuropsychological tests; performance; placebos; posture; socioeconomics

DESCRIPTION (adapted from the applicant's abstract): Previous studies have shown that succimer is a soft tissue chelator of lead; therefore, potential neurobehavioral health benefits may be expected. However, most of the published studies focused their attention toward succimer's ability to reduce blood lead level without evaluating its impact on neurobehavioral health. The proposed cross-sectional study is designed to evaluate the fine motor and gross motor proficiency as well as postural balance and gait in 200 children [from the Cincinnati Clinical Center for Treatment of Lead in Children (TLC)] who are currently active in a randomized double blind clinical trial designed to assess the effects of lead chelation using the drug succimer. In the proposed study, we will be assessing postural balance and gait and fine and gross motor development after the TLC children have completed their succimer or placebo program and the TLC follow-up period. The postural balance and gait and fine and gross motor assessments will be carried out with established techniques which have been used by us over 13 years on the Cincinnati Lead Program Project (LPP) cohort. The postural balance and gait will be assessed with a microprocessor-based force platform system along with a test protocol which indirectly assesses the roles of various physiological systems relevant for postural balance. The fine motor and gross motor assessments will be carried out using the comprehensive Bruininks-Oserestsky Test of Motor Proficiency (BOTMP) test battery. The TLC clinical trial of succimer is focused mainly on global measures of cognitive development. Assessments of motor development in the gross and fine motor spheres, postural balance and locomotion are not emphasized. Thus, this study will make a unique contribution to our understanding of the developmental benefits of chelation therapy and other measures to reduce lead in the range of exposures that are being considered. Our published findings from Cincinnati LPP cohort with the proposed motor development measurement instrument (BOTMP), postural balance test and locomotion test indicate that these measurement techniques are sensitive and, compared to cognitive measures are relatively uninfluenced by socioeconomic cofactors. Thus, the project has significance for furthering out understanding of the clinical benefits of succimer on developmental aspects of postural balance, locomotional outcomes and fine and gross motor functions in the developing central nervous system in socioeconomically disadvantaged populations.

描述（改编自申请人的摘要）：以前的研究已经 表明琥珀酸是铅的软组织螯合剂；因此，潜在的 神经行为健康方面的益处是可以预期的。 然而，大多数 已发表的研究将注意力集中在琥珀酸的能力上 降低血铅水平而不评估其对神经行为的影响 健康。 拟议的横断面研究旨在评估精细 运动和粗大运动的熟练程度以及姿势平衡和步态 200 名儿童 [来自辛辛那提铅治疗临床中心 儿童（TLC）]目前活跃于随机双盲研究中 旨在评估铅螯合效果的临床试验 药物琥珀酸。 在拟议的研究中，我们将评估姿势平衡 TLC 儿童的步态以及精细和粗大运动发育 完成了他们的琥珀酸或安慰剂计划以及 TLC 随访期。 姿势平衡、步态以及精细和粗大运动评估将 采用我们已使用超过 13 年的既定技术进行 在辛辛那提领导计划项目 (LPP) 队列中工作了数年。 姿势 平衡和步态将通过基于微处理器的力平台进行评估 系统以及间接评估角色的测试协议 与姿势平衡相关的各种生理系统。 精细马达 粗大运动评估将使用综合 Bruininks-Oserestsky 电机熟练程度测试 (BOTMP) 测试电池。 这 琥珀酸的 TLC 临床试验主要集中于全球测量 认知发展。 总体和运动发育评估 精细运动领域、姿势平衡和运动没有得到强调。 因此，这项研究将为我们理解 螯合疗法和其他措施的发育益处，以减少 正在考虑的暴露范围内的铅。 我们发表的 辛辛那提 LPP 队列的研究结果以及拟议的运动发育 测量仪（BOTMP）、姿势平衡测试和运动测试 表明这些测量技术是灵敏的，并且与 认知测量相对不受社会经济辅助因素的影响。 因此，该项目对于进一步加深对这一问题的认识具有重要意义。 琥珀酸对姿势平衡发育方面的临床益处， 发育中的运动结果以及精细和粗大运动功能 社会经济弱势群体的中枢神经系统。