MOTION PERCEPTION AND PURSUIT IN CEREBRAL CORTEX

大脑皮层的运动感知和追踪

• 批准号: 2891422
• 负责人: Jason J Barton
• 金额: $ 10.79万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891422
• 关键词: behavioral /social science research tag; brain mapping; cerebral cortex; clinical research; functional magnetic resonance imaging; human subject; motion perception; neuropsychology; psychophysics; scotoma; smooth pursuit eye movement

The investigator will develop expertise in visual psychophysics and create a program for exploring processes underlying visual motion perception and pursuit eye movements in human cerebral cortex. The investigator is experienced in eye movement studies and will work with a mentor who is expert in visual perception. While work is monkeys has delineated numerous cerebral areas participating in motion perception and pursuit, less is known about the regions involved in these processes in humans. However, recent developments in function and structural imaging in humans have the potential to advance our knowledge of human cerebral function. The investigator proposes a novel dual approach to localization. Motion perception and pursuit will be studied in patients with lesions mapped by detailed magnetic resonance images (MRI). Concurrently, similar motion perception and pursuit tasks will be given to normal subjects undergoing functional MRI. Lesion and functional imaging will provide complimentary information, and guide each other's progress. Based on hypothesis generated from current knowledge, we will (1) explore potential differences between the use of visual motion in defining the form of objects versus detecting self-motion, (2) study visual motion, feedback, and prediction in pursuit, and (3) follow patients to learn how complex, visual dysfunction recovers after natural human lesions. We will also (4) investigate the intriguing location of the underlying lesion. In sum, the investigator will join sophisticated visual and ocular motor measure to modern neuro-imaging of structure and function. It is anticipated that these studies will advances our knowledge of the human anatomy of motion processing as a system and also develop new approaches to emerging methodology in brain localization.

研究者将在视觉心理物理学方面发展专业知识，并创建 一个用于探索视觉运动感知基础过程的程序和 人类大脑皮层的追捕眼运动。调查员是 在眼动研究方面经验丰富，并将与一位导师合作 视觉感知专家。虽然工作是猴子，但已经描绘了许多 参与运动感知和追求的脑区域，更少的是 知道人类这些过程所涉及的地区。然而， 人类功能和结构成像的最新发展具有 潜力提高我们对人类脑功能的了解。这 研究者提出了一种新颖的双重定位方法。运动 在映射的病变患者中，将研究感知和追捕 详细的磁共振图像（MRI）。同时，类似的运动 将对正在接受的正常受试者进行感知和追求任务 功能性MRI。病变和功能成像将提供免费 信息，并指导彼此的进度。基于假设 根据当前知识产生的，我们将（1）探索潜力 视觉运动在定义形式的形式之间的差异 对象与检测自我运动，（2）研究视觉运动，反馈， 和追求的预测，以及（3）跟随患者学习多么复杂， 自然人体病变后，视觉功能障碍恢复。我们也将（4） 研究基础病变的有趣位置。总而言之 调查人员将将复杂的视觉和眼部运动量度加入 结构和功能的现代神经图像。预计 这些研究将提高我们对人类运动解剖结构的了解 作为系统处理，还开发了新的方法 大脑定位的方法。