HA AND TI COATINGS ON BONE/IMPLANT INTERACTIONS

HA 和 TI 涂层对骨/种植体相互作用的影响

基本信息

批准号：
2897156
负责人：
JOO L. ONG
金额：
$ 2.18万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-08-01 至 2001-07-31
项目状态：
已结题

项目摘要

DESCRIPTION: Biomaterials surfaces play an important role in the overall implant success. The objectives of this study are: to compare the performance of surface treated Ti implants to non-surface treated Ti implants in relation to bone implant interface and bone strength; and to investigate the long-term impact on bone remodeling as a result of loading the plasma sprayed titanium implants, plasma sprayed HA implants and non-surface treated TI implants. Aim will evaluate in vitro properties of plasma sprayed HA surfaces and compare their in vitro properties in cell culture medium containing serum with that of TI coated implants treated similarly. Aim 2 will compare the in vivo performance in dogs of plasma sprayed HA and TI implants with non- treated TI implants in terms of bone implant interface, interfacial strength, and coating resorption. Hypotheses to be tested are: 1) that the surface properties of HA coatings will be altered following in vitro incubation and thus will affect their in vivo stability; 2) prior to loading, the presence of plasma sprayed HA and TI coatings will result in an increase in bone implant bonding strength an greater bone apposition when compared to non-surface treated TI surfaces; and 3) after one year loading, differences in reverse torque and bone apposition will be observed among plasma sprayed HA and TI implants, and untreated TI implants. At present, implants are often placed clinically prior to the conduct of basic experimental studies elucidating the remodeling mechanisms that may enhance clinical serviceability. Data generated by this pilot study could provide needed information on HA surface properties, provide preliminary information on relationships among the different surfaced implants, and provide a basis for future long-term in vivo clinical studies, while suggesting an optimum surface treatment required for maximum implant stability. These result could reduce implant failures which are costly in terms of trauma, time, and money.

描述：生物材料表面在整体植入物成功。这项研究的目标是：比较表面处理过的Ti植入物的性能在非表面处理与骨植入物界面和骨强度有关的Ti植入物；和研究长期对骨骼重塑的影响加载血浆喷涂的钛植入物，血浆喷涂的HA植入物和未表面处理的Ti植入物。 AIM将在体外评估等离子体喷涂的HA表面的特性并比较其体外含有Ti的血清的细胞培养基中的特性涂层的植入物类似地处理。 AIM 2将比较体内血浆犬的性能，喷洒HA和Ti植入物，具有非 - 用骨植入物界面，界面处理的Ti植入物处理的Ti植入物强度和涂料吸收。要测试的假设是：1）体外后，HA涂层的表面特性将改变孵化，从而影响其体内稳定性； 2）之前加载，将导致血浆喷涂的HA和Ti涂层的存在在增加骨植入强度的骨骼中，更大的骨头与未经表面处理的Ti表面相比，请求； 3）一年后，反向扭矩和骨骼的差异在血浆喷涂的HA和Ti植入物中，将观察到并置。未处理的Ti植入物。目前，植入物通常在临床上放置在进行基础实验研究之前可以增强临床服务性的重塑机制。数据该试点研究产生的可能提供有关HA的所需信息表面特性，提供有关关系的初步信息在不同的表面植入物中，并为未来提供了基础长期体内临床研究，同时提出最佳表面最大植入物稳定性所需的治疗。这些结果可能在创伤，时间和钱。