IS BREAST CANCER STAGE OF DISEASE INFLUENCED BY STRESS?

乳腺癌的疾病阶段是否受到压力的影响？

• 批准号: 6013632
• 负责人: KARYN L ANGELL
• 金额: $ 8.22万
• 依托单位: OREGON RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6013632
• 关键词: behavioral /social science research tag; breast neoplasms; clinical research; coping; female; human subject; interview; neoplasm /cancer classification /staging; psychological aspect of cancer; social support network; stress

One of the major difficulties in investigating the relationship between life stress and cancer has been the definition and measurement of stress. In this project an interview-based, standardized measure of stress will be compared with a more traditional self-report life events checklist, and the associations between life stress and the severity of disease will be examined in a sample of breast cancer patients. The aims of this 2 year pilot project are to 1) develop collaborative relationships with local oncology clinics and practices in Eugene and Portland, OR, 2) establish a recruitment base of women with breast cancer in Western Oregon, 3) recruit a sample of 60 women with primary breast cancer to participate in a study on the associations between life stress and the severity of their disease at diagnosis, and 4) identify specific features of life stress, social support, and coping which may be critical to our understanding of the relationship between life stress and the progression of breast cancer. Participants will be recruited within one year of their diagnosis of breast cancer through medical centers. They will be sent a packet of questionnaires asking about life stress, social support and coping during the year preceding their diagnosis. They will then be interviewed in their homes using a semi-structured interview designed to tap 10 major areas of life experiences. The information from the interview will then be rated by trained Life Events and Difficulties (LEDS) raters, yielding interview-based assessments of life stress, social support and coping. Medical cancer history regarding the diagnosis and severity of disease will be collected during the interview and verified by chart review. This study is exploratory and will begin to clarify the nature of associations between stress and cancer progression, ultimately guiding the development of psychosocial and stress management interventions.

研究生命压力与癌症之间关系的主要困难之一就是压力的定义和测量。 在该项目中，将将基于访谈的标准压力度量与更传统的自我报告生活事件清单进行比较，并将在乳腺癌患者样本中检查生命压力与疾病严重程度之间的关联。 这个2年试验项目的目的是1）与尤金和波特兰的地方肿瘤学诊所和实践建立合作关系了解生命压力与乳腺癌进展之间的关系。 参与者将在通过医疗中心诊断出乳腺癌的一年内招募。 他们将在诊断之前向他们发送一包问卷，询问有关生活压力，社会支持和应对的问题。 然后，他们将使用半结构化访谈在他们的家中接受采访，旨在利用10个主要领域的生活体验。 然后，访谈中的信息将由受过训练的生活事件和困难（LED）评估者进行评估，从而对生活压力，社会支持和应对进行基于面试的评估。 有关疾病诊断和严重程度的医学癌症病史将在访谈期间收集，并通过图表审查进行验证。这项研究是探索性的，将开始阐明压力与癌症发展之间的关联性质，最终指导心理社会和压力管理干预措施的发展。