AGRICULTURAL CHEMICAL EXPOSURES AND CHILDHOOD CANCER

农业化学品接触与儿童癌症

• 批准号: 2906729
• 负责人: JOHN R NUCKOLS
• 金额: $ 7.24万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2906729
• 关键词: agriculture; cancer registry /resource; cancer risk; chemical carcinogen; chemical related neoplasm /cancer; clinical research; computer simulation; disease /disorder model; drug classification; environmental transport; geographic site; human data; information systems; model design /development; neoplasm /cancer epidemiology; pediatric neoplasm /cancer; pesticide biological effect; pesticides; plants; preschool child (1-5); telemetry

The purpose of this pilot study is to develop and evaluate an exposure metric designed for use in a case-control epidemiological investigation of childhood cancer and agricultural chemicals in California. The research design will build upon an existing collaborative effort between the principal investigators to improve the spatial resolution of the California Pesticide Use Reporting database(CPUR). Of the studies in the epidemiologic literature which bear on the possible pesticide/childhood cancer association, most suggest an increased risk. The methods to be employed in achieving the goal include: (1)To use remote sensing and geographic information system (GIS) technology to map crop locations in California in order to link agricultural pesticide use reported in CPUR to crops located near residences used in the case-control study; (2) To evaluate the exposure metric from Specific Aim 1 in terms of (a) integration with more advanced computer models for pesticide transport in the environment, (b) reduction in misclassification of exposure, and (c) transferability across the State of California; and (3) To conduct a pilot epidemiological study using the exposure metric developed by Specific Aim 1.

这项试点研究的目的是开发和评估旨在用于对儿童癌症和加利福尼亚州儿童癌症的流行病学研究的曝光度量。 研究设计将基于主要研究人员之间现有的合作努力，以改善加利福尼亚农药使用报告数据库（CPUR）的空间解决方案。 在可能的农药/儿童癌症协会的流行病学文献中的研究中，大多数表明风险增加。 用于实现目标的方法包括：（1）使用遥感和地理信息系统（GIS）技术来绘制加利福尼亚州的农作物位置，以将CPUR中报道的农药使用链接到案例对照研究中使用的住所附近的农作物； （2）评估（a）与环境中农药运输的更先进的计算机模型的集成，（b）降低暴露率的较低计算机模型，以及（c）在整个加利福尼亚州的转移性，以（a）整合到环境中的农药运输中，以（a）整合到了（a）整合到环境中的农药运输中，以评估来自特定目标1的暴露度量的暴露度量； （3）使用特定目标1开发的暴露度量进行试验流行病学研究。