EFFICACY OF PSYCHOSOCIAL THERAPIES FOR DRUG ABUSE

心理社会疗法对药物滥用的疗效

• 批准号: 2739114
• 负责人: LISA M NAJAVITS
• 金额: $ 7.44万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-10 至 2004-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2739114
• 关键词: HIV infections; alcoholism /alcohol abuse; behavioral /social science research tag; bipolar depression; clinical research; clinical trials; cocaine; cognitive behavior therapy; comorbidity; drug abuse therapy; female; health care quality; health care service evaluation; homeless; human subject; human therapy evaluation; motivation; posttraumatic stress disorder; prognosis; psychopharmacology; relapse /recurrence; social psychology; urban poverty area; women's health

The primary aim of this K02 application is to further the applicant's career in improving the efficacy of psychosocial treatments for patients with substance use disorder, comprising three subsidiary aims: (1) an emphasis on psychosocial treatments for "poor prognosis" substance use disorder (SUD) populations (e.g., patients who have co-occurring posttraumatic stress disorder or bipolar disorder, low motivation for treatment, or HIV; are poor and/or homeless; and inner-city women); (2) improving the quality of treatment of treatment delivery by psychosocial clinicians; and (3) developing new assessment measures to assist the above goals, for both research and clinical use. The K02 award would be useful to strengthen the applicant's involvement in the following eight studies, six of which are NIDA-funded: (1) Group Cognitive-Behavioral Therapy for Dual Diagnosis Women (and HIV supplement), a controlled randomized trial comparing a new cognitive-behavioral group psychotherapy developed by the applicant for women with posttraumatic stress disorder (PTSD) and SUD versus a "treatment-as-usual" control; a supplement to the grant focuses on reducing HIV risk behaviors in the sample; (2) A Relapse Prevention Group for Bipolar Substance Abusers to develop and pilot-test an integrated group therapy manual for patients with bipolar disorder and SUD; (3) Collaborative Cocaine Treatment Study, a multi-site randomized controlled trial comparing four psychosocial treatments for cocaine-dependent outpatients; (4) PTSD treatment outcomes for cocaine dependent women, a controlled randomized trial comparing the new cognitive-behavioral psychotherapy developed by the applicant versus standard relapse prevention for inner-city cocaine- dependent women with PTSD; (5) Validity of the ASAM Criteria for Drug Abuse Treatment, to test the validity of a widely used treatment- matching protocol and its applicability to a publicly funded population; (6) Research Diagnostic Project, to analyze the relationship between PTSD and SUD among 375 adult treatment-seeking patients; (7) Behavioral and Pharmacologic Treatment of Alcoholism, a multi-site controlled randomized trial comparing two psychosocial and two pharmacologic interventions for 720 outpatients with alcohol dependence; (8) PTSD and substance abuse among poor and homeless women (Smith-Richardson Foundation), a controlled randomized trial comparing the new cognitive- behavioral psychotherapy developed by the applicant versus "treatment- as-usual" for poor and/or homeless women with PTSD and SUD. The award would also enhance the applicant's potential to expand into related areas of research and to mentor new researchers.

本 K02 申请的主要目的是进一步提高申请人的能力 提高患者心理社会治疗效果的职业生涯 药物滥用障碍，包括三个附属目标：(1) 强调针对“预后不良”的药物滥用的心理社会治疗 疾病 (SUD) 人群（例如，同时患有 创伤后应激障碍或双相情感障碍，缺乏动力 治疗或艾滋病毒；贫穷和/或无家可归；和内城妇女）； (2) 通过社会心理提高治疗质量 临床医生； (3) 制定新的评估措施以协助 上述目标，用于研究和临床使用。 K02奖将是 有助于加强申请人对以下八项的参与 研究，其中六项是 NIDA 资助的：(1) 群体认知行为 双重诊断女性治疗（和艾滋病毒补充剂），一种对照 比较新认知行为组的随机试验 申请人为患有创伤后的女性开发的心理疗法 应激障碍 (PTSD) 和 SUD 与“照常治疗”对照；一个 该赠款的补充重点是减少艾滋病毒危险行为 样本; (2) 双相情感障碍药物滥用者复吸预防小组 为患者开发并试点测试综合团体治疗手册 患有双相情感障碍和 SUD； (3) 可卡因协同治疗 研究是一项多中心随机对照试验，比较了四项研究 对可卡因依赖的门诊患者进行心理社会治疗； (4)创伤后应激障碍 可卡因依赖妇女的治疗结果，一项对照随机 比较新的认知行为心理疗法的试验 申请人与市中心可卡因的标准复发预防相比- 患有创伤后应激障碍 (PTSD) 的受抚养妇女； (5) ASAM 药品标准的有效性 滥用治疗，测试广泛使用的治疗的有效性- 匹配协议及其对公共资助人群的适用性； (6) 研究诊断项目，分析之间的关系 375 名寻求治疗的成年患者的 PTSD 和 SUD； (7) 行为方面 和酒精中毒的药物治疗，多部位控制 比较两种心理社会和两种药理学的随机试验 对 720 名酒精依赖门诊患者进行干预； (8) 创伤后应激障碍和 贫穷和无家可归的妇女滥用药物（史密斯-理查森 基金会），一项对照随机试验，比较新的认知- 申请人开发的行为心理疗法与“治疗- 像往常一样”为患有创伤后应激障碍和 SUD 的贫穷和/或无家可归的妇女提供服务。该奖项 还将增强申请人扩展到相关领域的潜力 研究领域并指导新研究人员。