EFFICACY OF PSYCHOSOCIAL THERAPIES FOR DRUG ABUSE

心理社会疗法对药物滥用的疗效

• 批准号: 6362782
• 负责人: LISA M NAJAVITS
• 金额: $ 8.86万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-10 至 2004-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6362782
• 关键词: HIV infections; alcoholism /alcohol abuse; behavioral /social science research tag; bipolar depression; clinical research; clinical trials; cocaine; cognitive behavior therapy; comorbidity; drug abuse therapy; female; health care quality; health care service evaluation; homeless; human subject; human therapy evaluation; motivation; posttraumatic stress disorder; prognosis; psychopharmacology; relapse /recurrence; social psychology; urban poverty area; women's health

The primary aim of this K02 application is to further the applicant's career in improving the efficacy of psychosocial treatments for patients with substance use disorder, comprising three subsidiary aims: (1) an emphasis on psychosocial treatments for "poor prognosis" substance use disorder (SUD) populations (e.g., patients who have co-occurring posttraumatic stress disorder or bipolar disorder, low motivation for treatment, or HIV; are poor and/or homeless; and inner-city women); (2) improving the quality of treatment of treatment delivery by psychosocial clinicians; and (3) developing new assessment measures to assist the above goals, for both research and clinical use. The K02 award would be useful to strengthen the applicant's involvement in the following eight studies, six of which are NIDA-funded: (1) Group Cognitive-Behavioral Therapy for Dual Diagnosis Women (and HIV supplement), a controlled randomized trial comparing a new cognitive-behavioral group psychotherapy developed by the applicant for women with posttraumatic stress disorder (PTSD) and SUD versus a "treatment-as-usual" control; a supplement to the grant focuses on reducing HIV risk behaviors in the sample; (2) A Relapse Prevention Group for Bipolar Substance Abusers to develop and pilot-test an integrated group therapy manual for patients with bipolar disorder and SUD; (3) Collaborative Cocaine Treatment Study, a multi-site randomized controlled trial comparing four psychosocial treatments for cocaine-dependent outpatients; (4) PTSD treatment outcomes for cocaine dependent women, a controlled randomized trial comparing the new cognitive-behavioral psychotherapy developed by the applicant versus standard relapse prevention for inner-city cocaine- dependent women with PTSD; (5) Validity of the ASAM Criteria for Drug Abuse Treatment, to test the validity of a widely used treatment- matching protocol and its applicability to a publicly funded population; (6) Research Diagnostic Project, to analyze the relationship between PTSD and SUD among 375 adult treatment-seeking patients; (7) Behavioral and Pharmacologic Treatment of Alcoholism, a multi-site controlled randomized trial comparing two psychosocial and two pharmacologic interventions for 720 outpatients with alcohol dependence; (8) PTSD and substance abuse among poor and homeless women (Smith-Richardson Foundation), a controlled randomized trial comparing the new cognitive- behavioral psychotherapy developed by the applicant versus "treatment- as-usual" for poor and/or homeless women with PTSD and SUD. The award would also enhance the applicant's potential to expand into related areas of research and to mentor new researchers.

该K02申请的主要目的是进一步 改善心理社会疗法对患者的疗效的职业 使用药物使用障碍，包括三个子公司的目标：（1） 强调“预后不良”药物使用的社会心理治疗 疾病（SUD）种群（例如，同时发生的患者 创伤后应激障碍或躁郁症，动力低 治疗或艾滋病毒；贫穷和/或无家可归；和城市妇女）； （2） 通过社会心理提高治疗交付的治疗质量 临床医生； （3）制定新的评估措施以协助 高于目标，用于研究和临床使用。 K02奖将是 有助于加强申请人参与以下八个 研究，其中六个是NIDA资助的：（1）群体认知行为 双重诊断妇女（和艾滋病毒补充剂）的治疗，受控的 比较新认知行为群体的随机试验 申请人为创伤后女性开发的心理治疗 应激障碍（PTSD）和SUD与“与常态治疗”的控制；一个 补助金的补充侧重于减少艾滋病毒风险行为 样本; （2）双极物质滥用者的复发组 为患者开发和试验一本集成的组治疗手册 双相情感障碍和SUD； （3）可卡因治疗 研究，一个比较四个的多站点随机对照试验 可卡因依赖性门诊患者的社会心理治疗； （4）PTSD 可卡因依赖性女性的治疗结果，一个受控的随机治疗 试验比较了新的认知行为心理疗法 城市可卡因的申请人与预防标准复发 - 具有PTSD的依赖妇女； （5）ASAM药物标准的有效性 滥用治疗，以测试广泛使用治疗的有效性 - 匹配协议及其适用于公共资助人口； （6）研究诊断项目，分析 375名寻求治疗患者的PTSD和SUD； （7）行为 和酒精中毒的药理学治疗，这是一种多站点受控的 比较两种心理社会和两个药理的随机试验 饮酒依赖的720名门诊患者的干预措施； （8）PTSD和 穷人和无家可归的妇女滥用毒品 基金会），一项受控的随机试验，比较了新的认知 - 申请人与“治疗”开发的行为心理疗法 - 与PTSD和SUD的穷人和/或无家可归的妇女相同的“ 还将增强申请人扩展到相关的潜力 研究领域并指导新研究人员。