RESEARCH FACILITIES FOR DRUG DISCOVERY AND SYNTHESIS

药物发现和合成研究设施

• 批准号: 6039189
• 负责人: G. MARC LOUDON
• 金额: $ 100万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6039189
• 关键词: biomedical facility; building /facility design /renovation; drug design /synthesis /production; drug discovery /isolation

This proposal is to request funds for renovation of some of the existing medicinal chemistry research facilities in the Robert E. Heine Pharmacy Building (RHPH) at Purdue University. The renovated facilities will house NIH-sponsored research in Drug Discovery and Synthesis conducted in the Medicinal Chemistry and Molecular Pharmacology (MCMP) Department of Purdue's School of Pharmacy and Pharmacal Sciences. The long-term objectives of Drug Discovery and Synthesis research is to make fundamental advances, and to train graduate and postdoctoral researchers in: 1. Drug Discovery: the development of leads for new drugs from natural sources, from fundamental studies of biochemical systems, and from molecular modeling. 2. Drug Synthesis: the development of workable and, in some cases, novel, syntheses of entities revealed by drug-discovery efforts. The long-term objectives of this construction project are to renovate completely the laboratories in RHPH that have become both worn out from thirty years of continuous usage and outmoded by modern safety considerations. A complete university-financed HVAC (heating, ventilation, and air-conditioning) renovation is part of this plan that will proceed concurrently with laboratory renovation. The specific aims of this proposal are to renovate medicinal chemistry laboratories on the third and fifth floors of RHPH as well as a community cold room on the fourth floor.

该建议是要求对普渡大学罗伯特E. Heine Pharmacy大楼（RHPH）的一些现有药物化学研究设施进行翻新资金。经过翻新的设施将容纳NIH赞助的在药物发现和合成中的研究，并在普渡大学药学院药学院药物和药理学系（MCMP）进行。药物发现和合成研究的长期目标是在：1。药物发现：从天然来源的新药铅开发，从生化系统的基本研究和分子建模中培训毕业生和博士后研究人员。 2。药物合成：可行的发展，在某些情况下是新颖的，是由药物发现努力揭示的实体的合成。该建筑项目的长期目标是完全翻新RHPH中的实验室，这些实验室既持续使用了三十年，又超过了现代安全考虑因素。完整的大学资助HVAC（供暖，通风和空调）翻新是该计划的一部分，该计划将与实验室翻新一起进行。该提案的具体目的是在RHPH的第三层和第五层以及四楼的社区冷藏室中翻新药物化学实验室。