CHEMICAL IDENTIFICATION OF PEPTIDE HORMONES

肽激素的化学鉴定

• 批准号: 3292762
• 负责人: G. MARC LOUDON
• 金额: $ 8.9万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-21 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3292762
• 关键词: amides; chemical structure; chemical synthesis; hormone metabolism; peptide hormone

Chemistry is described that should serve as the basis for the chemical recognition and analysis of peptide hormones in their biological milieu. The basis of the assay is the fact that many peptide hormones possess carboxylterminal amide functionality; the chemistry described is specific for this functional group. Once the chemistry has been developed, it will be "field-tested" with extracts of biological tissues known to contain peptide hormones and then applied to the discovery of new peptide hormones in other tissues. The method in principle is more sensitive than existing methods by several orders of magnitude, and may lead to the identification of hitherto unrecognized peptide modulators of diverse biological responses.

描述了化学作用，应作为 化学识别和分析其肽激素 生物环境。 该测定的基础是许多事实 肽激素具有羧基末端酰胺功能； 所描述的化学是该功能组的特异性。 一旦开发了化学，它将进行“现场测试” 与已知含有肽的生物组织提取物 激素，然后应用于新肽的发现 其他组织中的激素。 原则上的方法更多 比现有方法敏感的几个数量级， 并可能导致迄今未认可的识别 不同生物学反应的肽调节剂。