CORE--GENETIC ANALYSIS

核心--遗传分析

• 批准号: 6109791
• 负责人: Morton P Printz
• 金额: $ 25.51万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6109791
• 关键词: animal genetic material tag; animal tissue; biomedical facility; familial hypertension; genetic strain; genotype; linkage mapping; molecular genetics; phenotype; quantitative trait loci; restriction fragment length polymorphism; tissue /cell preparation

Core C contains three Subcores designated by their specific functions to the overall goal of Core C, namely conducting genetic analyses of the phenotypic traits under study by projects of the Program. These phenotypic traits, important to an understanding of hypertension and target organ damage, include the following: resting blood pressure and heart rate (an essential trait for all projects); airpuff stress responses; cardiovascular responses to spinal nicotinic receptors and excitatory amino acids; renal function traits and transcriptional factor regulation of the AP1 and NFkappaB genes.

核心 C 包含三个按其特定功能指定的子核心 核心C的总体目标，即进行遗传分析 该计划项目正在研究的表型性状。这些表型 特征，对于了解高血压和靶器官很重要 损害，包括以下内容：静息血压和心率（ 所有项目的基本特征）；吹气应激反应； 心血管对脊髓烟碱受体的反应和兴奋性 氨基酸；肾功能特征和转录因子调控 AP1 和 NFkappaB 基因。