COLLECTION AND EVALUATION OF HUMAN TISSUES

人体组织的收集和评估

• 批准号: 3725532
• 负责人: BENJAMIN F TRUMP
• 金额: $ 54.07万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-03-31 至 1997-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3725532
• 关键词: cancer information system; histochemistry /cytochemistry; histopathology; human tissue; immunocytochemistry; ischemia; light microscopy; lung neoplasms; medical records; neoplasm /cancer epidemiology; postmortem; scanning electron microscopy; tissue donors; tissue resource /registry; transmission electron microscopy

The objectives of this acquisitions are: with approvals from relevant Contractor's internal review committees, and with informed consent from donors of their next-of-kin, to collect human tissues, cells, and fluids (i.e., lung, liver, bronchus, colon, pancreas, blood urine, pleural effusions) at the time of surgery and at autopsy from patients with medical and personal histories (epidemiological profiles), also available by informed consent. Autopsies will be both immediate (2 hrs.) and intermediate (12 hrs.) and specimens are to be delivered within 2 hours of availability from the pathologist, at anytime of day or night, while patient profiles (stored with coded references to protect the identity of the donors) will be securely stored in the contractor's facility until delivered to the NIH at the request of the Project Officer. In addition, selected specimens will be examined (characterized) for histopathological condition by light and EM microscopy, in vitro viability and the detection of various cellular components such as hormones and oncogenes by histochemistry, including immunological methods.

本次收购的目的是： 经相关部门批准 承包商的内部审查委员会，并征得承包商的知情同意 近亲的捐赠者，收集人体组织、细胞和液体 （即肺、肝、支气管、结肠、胰腺、血尿、胸膜 积液）在手术时和尸检时对患者进行 还提供医疗和个人史（流行病学概况） 经知情同意。尸检将立即进行（2 小时） 中间（12小时）和标本将在2小时内交付 病理学家可以在白天或晚上的任何时间提供服务，同时 患者档案（存储有编码参考以保护身份 捐赠者的信息）将被安全地存放在承包商的设施中，直到 应项目官员的要求交付给 NIH。此外， 选定的标本将进行组织病理学检查（表征） 通过光学和电子显微镜观察条件，体外活力和 检测各种细胞成分，如激素和癌基因 通过组织化学，包括免疫学方法。