Aspen Cancer Conf:Mech of Toxic, Carcin & Canc Preven

阿斯彭癌症会议：有毒、致癌的机制

• 批准号: 6507905
• 负责人: BENJAMIN F TRUMP
• 金额: $ 0.5万
• 依托单位: ASPEN CANCER CONFERENCE, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-18 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6507905
• 关键词: cancer prevention; carcinogenesis; cytotoxicity; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): The Aspen Cancer Conference, a series of annual scientific meetings, was begun in 1985. The 2002 Conference will be the seventeenth in the series that emphasizes the mechanisms and relationships between toxicity and carcinogenesis and the identification of novel strategies in cancer prevention, diagnosis, and therapy. The Conference organizers recognize that new paradigms are needed to explain that an increasing number of non-mutagenic agents result in carcinogenesis, that cell injury and death, repair, and inflammation are constant companions of cancer development, and that what has been termed "tumor promotion" is a very complex issue. The purpose of these meetings continues to be assembly of a group of leading scientists working in a wide range of disciplines representing industry, academia, and government, including regulatory agencies, to confer formally and informally on current concepts and aspects of research which transcend the normal boundaries. The unique assembly of these various groups has resulted in stimulated productive discussion leading to fruitful collaborations between scientific groups who do not typically interact. The Aspen Cancer Conference format is designed to encourage ample interaction among participants with twenty minute presentation followed by twenty minutes of discussion in the morning and early afternoon, lunch immediately following whereby discussions continue, and afternoon leisure periods where these interactions have historically continued. The introduction of the Young Investigator Program several years ago has introduced graduate students, medical students, veterinary students, post-doctoral fellows and young faculty into this interactive, informal program. These Young Investigators present posters and discuss, in a relaxed setting, their scientific findings with many of the leaders in their respective fields of study. The informal setting at The Gant Conference Center in Aspen, Colorado and the limited number of participants the Center will accommodate contribute significantly to the successful interaction of these various scientists. With a maximum of eighty-five participants, greater than fifty percent of whom are newcomers each year, this valuable interaction will successfully continue. During recent years, emphasis has focused increasingly on the molecular aspects of toxicity and carcinogenesis, and the relationship between the two as they relate to human risk. The Seventeenth Aspen Cancer Conference in 2002 will address the following: Chromatin Remodeling; Genetic Instability; Protein Degradation; Rational Cancer Therapy; Development and Cancer; Emerging Technology in Pharmacological Research and Development; Pharmacogenetics and Molecular Diagnostics; Stem Cells; Cellular Stress and Signal Transduction; Animal Models; Safety Assessment in the Development of Chemotherapeutics, and Mitochondrial Structure and Function in Cell Death. The 2002 Conference will feature a special lecture on "Molecular Targets of Cancer Therapy" to be presented by a prominent scientist, Dr. Richard D. Klausner. His lecture will be follow by a panel discussion with representatives from government and industry.

描述（由申请人提供）： 阿斯彭癌症会议（一系列年度科学会议）开始了 1985 年举行。2002 年会议将是该系列会议中的第十七次 强调毒性和毒性之间的机制和关系 致癌作用和癌症新策略的确定 预防、诊断和治疗。会议组织者认识到 需要新的范式来解释越来越多的非诱变 致癌物质导致细胞损伤和死亡、修复和 炎症是癌症发展的常伴，这就是为什么 被称为“肿瘤促进”是一个非常复杂的问题。这些的目的 会议仍然是一群在以下领域工作的顶尖科学家的聚会 代表工业界、学术界和政府的广泛学科， 包括监管机构，正式和非正式地就当前的情况进行协商 超越正常界限的研究概念和方面。这 这些不同群体的独特组合刺激了生产力 讨论导致科学团体之间富有成效的合作 通常不会交互。阿斯彭癌症会议的形式旨在 通过二十分钟的演示鼓励参与者之间充分互动 接下来是上午和下午早些时候的二十分钟讨论， 午餐后立即继续讨论，下午 这些互动在历史上一直持续的休闲时期。这 几年前推出的青年研究员计划 介绍了研究生、医学生、兽医生、 博士后研究员和年轻教师参与到这个互动的、非正式的 程序。这些年轻的研究者在轻松的氛围中展示海报并进行讨论 环境，他们的科学发现与他们的许多领导者 各自的研究领域。甘特会议的非正式环境 位于科罗拉多州阿斯彭的中心，该中心的参与者数量有限 将为双方的成功互动作出重大贡献 这些不同的科学家。参加人数最多为八十五人， 每年超过百分之五十的人是新来者，这种宝贵的互动 将成功继续。近年来，重点集中在 越来越多地关注毒性和致癌作用的分子方面，以及 两者之间的关系，因为它们与人类风险有关。第十七号 2002 年阿斯彭癌症会议将讨论以下问题：染色质 改造；遗传不稳定性；蛋白质降解；合理的癌症治疗； 发育与癌症；药理学研究的新兴技术和 发展;药物遗传学和分子诊断；干细胞；蜂窝网络 压力和信号传导；动物模型；安全评估 化疗药物的发展以及线粒体结构和功能 细胞死亡。 2002年会议将有一个关于“分子 癌症治疗的目标》由著名科学家 Dr. 理查德·D·克劳斯纳。他的演讲之后将进行小组讨论 来自政府和行业的代表。