Overcoming the Limitations of Allograft in Impaction Bone Grafting for Revision Arthroplasty

克服同种异体移植在打压骨移植修复关节置换术中的局限性

基本信息

批准号：
G0802397/1
负责人：
Richard Oreffo
金额：
$ 58.89万
依托单位：
University of Southampton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2010
资助国家：
英国
起止时间：
2010 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=G0802397%2F1
关键词：
Overcoming Limitations Allograft Impaction Bone

项目摘要

The replacement of lost bone is a major clinical and socio-economic need, particularly in the fields of revision arthroplasty, spinal and trauma surgery. Often, a lack of sufficient host (own or autogenous) bone precludes the universal use of autogenous bone while the use of donor (allogeneic) bone carries risks of rejection and infection. Bone marrow contains stem cells (skeletal stem cells), which can be isolated and can be readily expanded, while retaining their ability to form a variety of tissues like bone and fat. Given the demographic challenge of an ageing population, the development of strategies to exploit the potential of bone progenitors which can give rise to cells of the osteogenic lineage, offers a compelling approach to augment bone formation to replace or restore the function of traumatised or degenerated bone. We propose a unique programme to create a living composite of bone progenitor cells and a synthetic scaffold together with a new innovative process for placing the synthetic polymer scaffold and cells in the hip cavity ( a process of vibration impaction bone grafting)that can be applied in orthopaedic applications requiring new bone stock. We will show in this work the ability of bone progenitor cells together with an optimised synthetic scaffold and an innovative vibration impaction process our ability to augment bone formation in impaction bone grafting. To prove our concept, we will use a standard clinical orthopaedic procedure called femoral impaction grafting wherein a new prosthesis is needed to replace a degenerated hip implant and needs bone stock.

替换骨骼的替代是主要的临床和社会经济需求，尤其是在修订节关节置换术，脊柱和创伤手术领域。通常，缺乏足够的宿主（自动或自体）骨骼阻止了自动骨的普遍使用，而使用供体（同种异体）骨会带来排斥和感染的风险。骨髓含有干细胞（骨骼干细胞），可以分离并容易扩展，同时保持其形成各种组织等多种组织等能力。鉴于人口衰老的人口挑战，开发了利用骨祖细胞潜力的策略，从而引起成骨谱系的细胞，因此提供了一种令人信服的方法来增强骨形成，以替代或恢复创伤或退化的骨骼的功能。我们提出了一个独特的程序，以创建骨祖细胞和合成支架的活体复合物，以及一个新的创新过程，用于将合成聚合物支架和细胞放置在髋腔中（振动撞击的过程）（一种可以应用于需要新骨骼库存的矫形器应用中）。我们将在这项工作中展示骨祖细胞的能力以及优化的合成支架和创新的振动撞击过程，我们在撞击骨移植中增强骨形成的能力。为了证明我们的概念，我们将使用一种标准的临床骨科手术，称为股骨撞击术，其中需要新的假体来替代退化的髋关节植入物并需要骨骼库存。