Device for Enrichment of Skeletal Stem Cells for Orthopaedic Applications

用于骨科应用的骨骼干细胞富集装置

基本信息

批准号：
TS/G001650/1
负责人：
Richard Oreffo
金额：
$ 50.32万
依托单位：
University of Southampton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=TS%2FG001650%2F1
关键词：
Device Enrichment Skeletal Stem Cells

项目摘要

With an increasing ageing population, strategies that allow the simple repair and augmentation of bone tissue, lost as a consequence of trauma or disease or with ageing, are urgently needed.The ability to develop a device that would allow the simple enrichment of skeletal stem cells from the bone marrow of a patient for orthopaedic application is thus an unmet and urgently required clinical target. This project proposes to progress the development of a unique and patented cell separation technology, developed by Smith and Nephew into a clinically effective and commercially viable surgical device. The implications for orthopaedic use are immense and potential for improving the quality of life in an increasing ageing population significant.This novel technology has the potential to transform orthopaedic clinical practice by increasing the accessibility of enriched autologous marrow. The Southampton group, includes clinicians and basic scientists, that will evaluate the device using human bone marrow samples and, through experimental studies aid in the evaluation and, if necessary, additional development of the cell separation device. The ability of the device to enrich for skeletal stem cells will be assessed by a battery of assays as well as unique models of bone formation available within Southampton.The collaboration between academic, industrial and clinical researchers will allow rapid development of the cell enrichment device and, critically, evaluation with human tissue to include pre-clinical study. This will allow us, within a 2 year time frame, to significantly contribute in Southampton to the programme of work from S&N to the generation of the regulatory data needed to allow clinical use of the proposed device.

随着人口衰老的越来越多，迫切需要由于创伤或疾病或衰老而丧失的骨骼组织的策略，因此迫切需要开发一种设备的能力，从而使骨骼骨髓中的骨骼干细胞从骨科施加的患者的骨髓中简单富集的能力是无效的，并且是无效的临床目标。该项目提出，旨在发展由Smith和Nephew开发的独特和专利的细胞分离技术，为临床有效且在商业上可行的手术装置。对骨科使用的影响是巨大的，并且有可能改善衰老人群的生活质量的潜力。这种新型技术有可能通过提高丰富自体骨髓的可及性来改变骨科临床实践。南安普敦组包括临床医生和基本科学家，将使用人骨髓样品评估该设备，并通过实验研究有助于评估，并在必要时进行细胞分离装置的额外开发。该设备丰富骨骼干细胞的能力将通过一系列测定法以及在南安普敦内提供的独特骨形成模型来评估。学术，工业和临床研究人员之间的合作将允许快速开发细胞富集设备，并严格开发与人类组织的评估，包括预先临床研究。这将使我们在2年的时间范围内，在南安普敦（Southampton）为从S＆N到生成允许临床使用该拟议设备所需的监管数据的工作计划做出了重大贡献。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

ENRICHMENT OF SKELETAL STEM CELLS FROM BONE MARROW TO ENHANCE SKELETAL REGENERATION - A NOVEL CLINICAL TECHNIQUE

富集骨髓中的骨骼干细胞以增强骨骼再生——一种新颖的临床技术

DOI：
发表时间：
2011
期刊：
影响因子：
0
作者：
Alex Aarvold
通讯作者：
Alex Aarvold

A clinical strategy to concentrate aspirated bone marrow for skeletal stem cells to enhance skeletal regeneration

浓缩抽吸骨髓用于骨骼干细胞以增强骨骼再生的临床策略

DOI：
发表时间：
2011
期刊：
影响因子：
0
作者：
Alex Aarvold
通讯作者：
Alex Aarvold

A tissue engineering strategy for the treatment of avascular necrosis of the femoral head.

DOI：
10.1016/j.surge.2013.02.008
发表时间：
2013-12
期刊：
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
影响因子：
2.5
作者：
Aarvold, A.;Smith, J. O.;Tayton, E. R.;Jones, A. M. H.;Dawson, J. I.;Lanham, S.;Briscoe, A.;Dunlop, D. G.;Oreffo, R. O. C.
通讯作者：
Oreffo, R. O. C.

Taking tissue engineering principles into theatre: retrieval analysis from a clinically translated case.

将组织工程原理带入临床：临床转化病例的检索分析。