REGULATION OF HUMAN T CELL RESPONSES BY ADHERENT CELLS

贴壁细胞对人类 T 细胞反应的调节

• 批准号: 3939372
• 负责人: G M SHEARER
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939372
• 关键词: cell adhesion; immune tolerance /unresponsiveness; immunoregulation; immunosuppression; leukocyte activation /transformation; macrophage; major histocompatibility complex; mumps virus; suppressor T lymphocyte; tissue /cell culture; virus antigen; cell adhesion; immune tolerance /unresponsiveness; immunoregulation; immunosuppression; leukocyte activation /transformation; macrophage; major histocompatibility complex; mumps virus; suppressor T lymphocyte; tissue /cell culture; virus antigen

Depletion of human peripheral blood leukocytes (PBL) of Leu M3+ cells by adherence to plastic and sephadex G10 results in the abrogation of proliferative (3H) and cytotoxic T lymphocyte (CTL) responses to influenza A virus (FLU), but in an elevation of 3H and CTL responses to HLA alloantigens (ALLO). This loss of the elevation of 3H and CTL responses to HLA alloantigens (ALLO). This loss of the FLU T cell response was attributed to removal of antigen-presenting cells (APC), whereas the elevation of the ALLO response was shown to be due to suppressor cell (or a suppressor inducer cell) that is contained in the Leu M3+ adherent cell population. Suppressor activity was inactivated by culturing either unfractionated PBL or adherent cells with viruses, including influenza A, measles and mumps viruses.

Leu M3+的人外周血白细胞（PBL）的耗竭 通过遵守塑料和Sephadex G10的细胞导致 废除增殖（3H）和细胞毒性T淋巴细胞（CTL） 对流感病毒（流感）的反应，但海拔3H 和CTL对HLA同种抗原（Allo）的响应。 损失 3H和CTL对HLA同种抗原（Allo）的升高。 流感细胞反应的这种损失归因于去除 抗原呈递细胞（APC），而升级 Allo响应显示是抑制细胞（或A LEU M3+粘附物中包含的抑制诱导器细胞） 细胞种群。 通过培养使抑制活性失活 未分流的PBL或具有病毒的粘附细胞， 包括流感，麻疹和腮腺炎病毒。