MURINE AND HUMAN AUTOIMMUNITY

鼠类和人类自身免疫

• 批准号: 2463771
• 负责人: G M SHEARER
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2463771
• 关键词: HIV envelope protein gp120; HIV infections; antiviral antibody; autoimmunity; cytokine; helper T lymphocyte; human tissue; immunopathology; immunoregulation; laboratory mouse; synthetic peptide; systemic lupus erythematosus

This laboratory has established that the pattern of T helper cell (Th) dysfunction seen in asymptomatic, HIV-seropositive (HIVs+) is also detected in patients with systemic lupus erythematosus (SLE). Thus, there are certain similarities between the immune dysregulation of SLE patients and HIV+ individuals. For example, mice immunized with the 16/6 idiotype exhibit a shift from a dominant type 1 to type 2 cytokine profile as they progress toward SLE. To investigate other possible similarities, we have tested the sera of SLE patients and mice with SLE-like diseases, and have found evidence of antibodies that recognize the gp120 of HIV, as well as certain synthetic peptides of HIV envelope. These results provide further evidence of similar immunodysregulatory events in SLE patients and individuals infected with HIV.

该实验室已经确定T辅助细胞的模式（Th） 在无症状，HIV - 呼吸阳性（HIVS+）中看到的功能障碍也是 在全身性红斑狼疮（SLE）的患者中检测到。 因此， SLE的免疫失调之间存在某些相似之处 患者和艾滋病毒+个体。 例如，用 16/6的白痴型表现出从主要类型1到2型细胞因子的转变 当它们向SLE进展时，剖面。 调查其他可能 相似性，我们已经测试了SLE患者和小鼠的血清 类似SLE的疾病，并找到了识别抗体的证据 HIV的GP120以及HIV的某些合成肽 信封。 这些结果提供了类似的进一步证据 SLE患者和感染的个体的免疫调节事件 与艾滋病毒。