DYNAMICS OF POSTISCHEMIC CALCIUM ACCUMULATION AND PROTEIN SYNTHESIS IN BRAIN

脑缺血后钙积累和蛋白质合成的动力学

• 批准号: 3860907
• 负责人: G MIES
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3860907
• 关键词: brain metabolism; calcium; cerebral ischemia /hypoxia; gamma aminobutyrate; heart arrest; hippocampus; inferior colliculus; laboratory rat; protein biosynthesis; reticular formation; thalamic nuclei

Increased calcium accumulation and decreased protein synthesis activity are sensitive indicators of brain damage after ischemia that provide insight into distinct components in the evolution of the injury process. Protein synthesis, largely reflecting neuronal elements, is lost immediately and uniformly in global ischemia models, recovers within hours in regions that are resistant to injury, but remains low in vulnerable regions such CA1 of hippocampus. Accumulation of 45Ca is a later component that occurs in surviving cells in regions where neuronal loss has already occurred. Calcium uptake studies have identified the GABAergic reticular nucleus of the thalamus as a particularly early site of injury in a rat cardiac arrest model. Detailed quantitative comparisons of these two indicators in this rat model will continue. This project is currently in a suspended state, and will be completed upon return of the principal investigator.

钙积累增加和蛋白质合成活性降低 是缺血后对脑损伤的敏感指标 在伤害过程的演变中深入了解不同的组成部分。 蛋白质合成，主要反映神经元元素，丢失 立即在全球缺血模型中立即恢复 在耐受伤害的地区的小时，但保持较低 脆弱区域的海马CA1。 45CA的积累是 后来在神经元的地区存活的细胞中发生的分量 损失已经发生。 钙吸收研究已经确定 丘脑的GABA能网状核作为特别早期的位置 大鼠心脏骤停模型受伤。 详细的定量 该大鼠模型中这两个指标的比较将继续。 该项目目前处于悬浮状态，将完成 首席研究员返回后。